Editorials - Study methodology

Comparative Effectiveness Research: Challenges for Medical Journals

By: Harold C Sox, Mark Helfand, Jeremy Grimshaw, Kay Dickersin, the PLoS Medicine Editors, David Tovey, J André Knottnerus & Peter Tugwell
On: April 27, 2010, 22:00

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In order to optimize health outcomes within the constraints of inevitably limited resources, low- and high-income countries alike require unbiased means of assessing health care interventions for their relative effectiveness. Such interventions include diagnostic tests and treatments (both established and newly developed) and implementation of health policy...

Systematic reviews and uncertainties about the effects of treatments

By: Sir Iain Chalmers
On: May 12, 2010, 09:00

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One of the common criticisms made of The Cochrane Collaboration is that most of its reviews don’t end with clear instructions for action by professionals, patients and policymakers. Since its inception, however, the Collaboration has made it clear that research evidence isn’t everything. Other factors need to be taken into account when people decide what action – if any – is needed when making treatment and policy decisions...

International Clinical Trials Day & The Cochrane Library

By: Mike Clarke
On: May 19, 2010, 08:00

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International Clinical Trials Day, 20 May 2010, is an opportunity to celebrate the role of clinical trials in resolving uncertainties in health care and a fitting day to mark within The Cochrane Library. A related series of podcasts discussing various aspects of clinical trials are available within the Special Collection for International Clinical Trials Day...

The role of Cochrane Review authors in exposing research and publication misconduct

By: Vasiliy Vlassov & Trish Groves
On: December 08, 2010, 14:07

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Study methodology

At the Joint Colloquium of the Cochrane & Campbell Collaborations in Keystone in October 2010, we ran a workshop about the problems of detecting research misconduct,[1] and had a wonderful discussion with participants. The US Office of Research Integrity defines research misconduct as...

If there are no randomised controlled trials, do we always need more research?

By: Karianne Thune Hammerstrøm & Arild Bjørndal
On: March 14, 2011, 14:32

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We have recently come across Cochrane Reviews in which evaluative research other than randomised controlled trials, as well as logic and basic science, seem to have been largely ignored. Hence, the review questions cannot be answered in the manner that the authors set out to do, the implication being that more research is needed...

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