Editorials - Evidence synthesis

Comparative Effectiveness Research: Challenges for Medical Journals

By: Harold C. Sox, Mark Helfand, Jeremy Grimshaw, Kay Dickersin, the PLoS Medicine Editors, David Tovey, J. André Knottnerus, Peter Tugwell
On: April 27, 2010, 22:00

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In order to optimize health outcomes within the constraints of inevitably limited resources, low- and high-income countries alike require unbiased means of assessing health care interventions for their relative effectiveness. Such interventions include diagnostic tests and treatments (both established and newly developed) and implementation of health policy...

International Clinical Trials Day & The Cochrane Library

By: Mike Clarke
On: May 19, 2010, 08:00

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International Clinical Trials Day, 20 May 2010, is an opportunity to celebrate the role of clinical trials in resolving uncertainties in health care and a fitting day to mark within The Cochrane Library. A related series of podcasts discussing various aspects of clinical trials are available within the Special Collection for International Clinical Trials Day...

If there are no randomised controlled trials, do we always need more research?

By: Karianne Thune Hammerstrøm & Arild Bjørndal
On: March 14, 2011, 14:32

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We have recently come across Cochrane Reviews in which evaluative research other than randomised controlled trials, as well as logic and basic science, seem to have been largely ignored. Hence, the review questions cannot be answered in the manner that the authors set out to do, the implication being that more research is needed...

The use of Cochrane Reviews in NICE clinical guidelines

By: Phil Alderson & Toni Tan
On: August 09, 2011, 10:46

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The National Institute for Health and Clinical Excellence (NICE) produces clinical guidelines for the National Health Service (NHS) in England and Wales. These guidelines are developed by groups that combine people with expertise in conducting systematic reviews and health economic analyses, with those with expertise in the clinical area (from healthcare professionals and patients). During guideline development, the group poses about 20 to 25 clinical questions, which are then addressed by systematic reviews. As described in the NICE Guidelines Manual, groups routinely search for existing relevant systematic reviews ...

Helping people make well-informed decisions before, during and after disasters: the Evidence Aid initiative

By: By Mike Clarke, Claire Allen and Bonnix Kayabu
On: November 07, 2011, 19:46

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As we watch the aftermath of the recent earthquake in Turkey and the ongoing flooding in Thailand, the need for reliable information on the effects of interventions and actions, by people engaged in disaster planning and response, feels ever more pressing. Evidence Aid, a global initiative that arose within The Cochrane Collaboration, is trying to meet this need ...

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