2013 Table of contents





Jonathan Sterne 

Cochrane Database Syst Rev. 2013 December 20;12:ED000076



Why the Cochrane risk of bias tool should include funding source as a standard item

Lisa Bero 

Cochrane Database Syst Rev. 2013 December 20;12:ED000075



A 747 in the age of A380s: how can Cochrane learn from the past and compete 20 years on?

Jonathan Craig, Jeremy Grimshaw & David Tovey 

Cochrane Database Syst Rev. 2013 December 18;12:ED000074


New Reviews

Agomelatine versus other antidepressive agents for major depression

Anticholinergic medication for non-clozapine neuroleptic-induced hypersalivation in people with schizophrenia 

Aripiprazole alone or in combination for acute mania 

Breathing exercises for dysfunctional breathing/hyperventilation syndrome in children 

Bronchoscopy-guided antimicrobial therapy for cystic fibrosis

Chest radiographs for acute lower respiratory tract infections 

Combination versus sequential single agent chemotherapy for metastatic breast cancer 

Combination formoterol and budesonide as maintenance and reliever therapy versus combination inhaler maintenance for chronic asthma in adults and children 

Conservative interventions for treating work-related complaints of the arm, neck or shoulder in adults

Ibuprofen and/or paracetamol (acetaminophen) for pain relief after surgical removal of lower wisdom teeth

Immunosuppressive drug therapy for preventing rejection following lung transplantation in cystic fibrosis 

Immunosuppressive T-cell antibody induction for heart transplant recipients 

Immunotherapy for idiopathic lumbosacral plexopathy 

Interdental brushing for the prevention and control of periodontal diseases and dental caries in adults

Interventions for promoting physical activity in people with cystic fibrosis

Interventions for the symptoms and signs resulting from jellyfish stings 

Larvivorous fish for preventing malaria transmission 

Lipid-lowering agents for nephrotic syndrome 

The Lund concept for severe traumatic brain injury 

Mass drug administration for malaria

Mechanical insufflation-exsufflation for people with neuromuscular disorders

Nerve blocks for initial pain management of femoral fractures in children 

Optimum duration of regimens for Helicobacter pylori eradication 

Passive movements for the treatment and prevention of contractures

Percussion, diuresis, and inversion therapy for the passage of lower pole kidney stones following shock wave lithotripsy

Pharmacological interventions for drug-using offenders 

Plasma transfusion strategies for critically ill patients

Platelet-rich therapies for musculoskeletal soft tissue injuries  

Primary prophylaxis for venous thromboembolism in people undergoing major amputation of the lower extremity  

Prophylactic versus selective blood transfusion for sickle cell disease in pregnancy

Psychosocial interventions for men with prostate cancer 

Rehabilitation following surgery for lumbar spinal stenosis

Resistance exercise training for fibromyalgia 

Selective computed tomography (CT) versus routine thoracoabdominal CT for high-energy blunt-trauma patients 

Statins for non-alcoholic fatty liver disease and non-alcoholic steatohepatitis

Strategies to improve retention in randomised trials

Telerehabilitation services for stroke 

Triclosan/copolymer containing toothpastes for oral health 

Vitamin A and fish oils for retinitis pigmentosa 

Water-based exercise training for chronic obstructive pulmonary disease


Updated Reviews

Antibacterial agents in composite restorations for the prevention of dental caries

Antibiotic use for irreversible pulpitis 

Antibiotics and antiseptics for venous leg ulcers 

Antibiotics for preterm rupture of membranes

Antiviral interventions for liver transplant patients with recurrent graft infection due to hepatitis C virus 

Antiviral prophylaxis for the prevention of chronic hepatitis C virus in patients undergoing liver transplantation  

Compression stockings for the initial treatment of varicose veins in patients without venous ulceration 

Daclizumab for relapsing remitting multiple sclerosis 

Dietary advice for reducing cardiovascular risk 

Electromagnetic fields for treating osteoarthritis 

Exercise programs for people with dementia 

Fetal manipulation for facilitating tests of fetal wellbeing

Fetal vibroacoustic stimulation for facilitation of tests of fetal wellbeing

Fibrinolytic agents for peripheral arterial occlusion  

Fluorides for the prevention of early tooth decay (demineralised white lesions) during fixed brace treatment 

Heliox for croup in children 

Hyperbaric oxygen therapy for treating acute surgical and traumatic wounds 

Interventions for preventing blood loss during the treatment of cervical intraepithelial neoplasia 

Intranasal steroids for acute sinusitis

Intravenous immunoglobulin for chronic inflammatory demyelinating polyradiculoneuropathy 

Lamotrigine for chronic neuropathic pain and fibromyalgia in adults

Local versus general anaesthesia for carotid endarterectomy 

Maintenance agonist treatments for opiate-dependent pregnant women

Management of faecal incontinence and constipation in adults with central neurological diseases 

Medical interventions for traumatic hyphema

Methods of repair for obstetric anal sphincter injury 

Mobile phone messaging reminders for attendance at healthcare appointments 

Music for stress and anxiety reduction in coronary heart disease patients

Non-antiepileptic drugs for trigeminal neuralgia  

Noninvasive positive-pressure ventilation as a weaning strategy for intubated adults with respiratory failure

Once or twice daily versus three times daily amoxicillin with or without clavulanate for the treatment of acute otitis media  

Pharmacological treatment for memory disorder in multiple sclerosis 

Phytoestrogens for menopausal vasomotor symptoms 

Pin site care for preventing infections associated with external bone fixators and pins

Planned elective repeat caesarean section versus planned vaginal birth for women with a previous caesarean birth 

Prophylactic antibiotics for inhibiting preterm labour with intact membranes 

Psychological therapies for chronic post-traumatic stress disorder (PTSD) in adults 

Radiofrequency (thermal) ablation versus no intervention or other interventions for hepatocellular carcinoma 

Recall intervals for oral health in primary care patients 

Rituximab for relapsing-remitting multiple sclerosis 

Spermicide used alone for contraception

Surgery for cervical intraepithelial neoplasia 

Surgery for post-vitrectomy cataract 

Surgical versus endoscopic treatment of bile duct stones 

Treatment of hypertension in peripheral arterial disease 

Wound drains after incisional hernia repair 

Wound drainage for caesarean section

Zonisamide add-on for drug-resistant partial epilepsy  



Serotonin receptor antagonists for highly emetogenic chemotherapy in adults (Withdrawn)



ISSUE 11 November 2013 (COMPLETE)

Reviews of qualitative evidence: a new milestone for Cochrane

A Metin Gülmezoglu, Jackie Chandler, Sasha Shepperd & Tomás Pantoja

Cochrane Database Syst Rev. 2013 November 8;11:ED000073



Cochrane and capacity building in low- and middle-income countries: where are we at?

Taryn Young, Paul Garner, Tamara Kredo, Lawrence Mbuagbaw, Prathap Tharyan & Jimmy Volmink

Cochrane Database Syst Rev. 2013 November 1;11:ED000072


New Reviews

Antibiotic therapy for the treatment of methicillin-resistant Staphylococcus aureus (MRSA) in non surgical wounds

Antibody induction therapy for lung transplant recipients

Antiepileptic drugs for neuropathic pain and fibromyalgia - an overview of Cochrane reviews 

Antiepileptic drugs for the treatment of severe myoclonic epilepsy in infancy 

Chromium picolinate supplementation for overweight or obese adults

Clinical assessment to screen for the detection of oral cavity cancer and potentially malignant disorders in apparently healthy adults 

Collaborative care approaches for people with severe mental illness

Diagnostic accuracy of laparoscopy following computed tomography (CT) scanning for assessing the resectability with curative intent in pancreatic and periampullary cancer 

Dilute versus full strength formula in exclusively formula-fed preterm or low birth weight infants

Enamel etching for bonding fixed orthodontic braces 

Follow-up protocols for women with cervical cancer after primary treatment 

Homeopathy for treatment of irritable bowel syndrome 

Lateral pararectal versus transrectal stoma placement for prevention of parastomal herniation 

Lifestyle interventions for acute gout

Non-specialist health worker interventions for the care of mental, neurological and substance-abuse disorders in low- and middle-income countries 

Nurse-led versus doctor-led preoperative assessment for elective surgical patients requiring regional or general anaesthesia

Nutritional interventions for reducing gastrointestinal toxicity in adults undergoing radical pelvic radiotherapy

Patient-reported outcome measures for follow-up after gynaecological cancer treatment 

Pelvic floor muscle training added to another active treatment versus the same active treatment alone for urinary incontinence in women

Pharmacotherapy for trichotillomania

Pre-operative endometrial thinning agents before endometrial destruction for heavy menstrual bleeding

Prophylactic antibiotic therapy for chronic obstructive pulmonary disease (COPD)  

Prophylactic interventions after delivery of placenta for reducing bleeding during the postnatal period 

Prostaglandins before caesarean section for preventing neonatal respiratory distress

Smartphone and tablet self management apps for asthma  

Tamoxifen or letrozole versus standard methods for women with estrogen-receptor positive breast cancer undergoing oocyte or embryo cryopreservation in assisted reproduction

The effect of different methods of remuneration on the behaviour of primary care dentists

Transcranial direct current stimulation (tDCS) for improving function and activities of daily living in patients after stroke


Updated Reviews

Antibiotics for sore throat

Blood transfusion for preventing primary and secondary stroke in people with sickle cell disease

Catheter policies for management of long term voiding problems in adults with neurogenic bladder disorders 

Chemotherapy versus best supportive care for extensive small cell lung cancer 

Combined corticosteroid and long-acting beta2-agonist in one inhaler versus placebo for chronic obstructive pulmonary disease 

Computerized advice on drug dosage to improve prescribing practice 

Continuous negative extrathoracic pressure or continuous positive airway pressure compared to conventional ventilation for acute hypoxaemic respiratory failure in children

Endometrial resection and ablation versus hysterectomy for heavy menstrual bleeding 

End-of-life care pathways for improving outcomes in caring for the dying 

Enzyme replacement therapy with laronidase (Aldurazyme®) for treating mucopolysaccharidosis type I 

Fetal and umbilical Doppler ultrasound in high-risk pregnancies 

Haloperidol versus placebo for schizophrenia 

Hydration for treatment of preterm labour

Infection control strategies for preventing the transmission of meticillin-resistant Staphylococcus aureus (MRSA) in nursing homes for older people 

Inspiratory muscle training for cystic fibrosis 

Interventions for hyperthyroidism pre-pregnancy and during pregnancy 

Omega-3 fatty acids for cystic fibrosis

Orthodontic treatment for prominent upper front teeth (Class II malocclusion) in children

Outpatient versus inpatient induction of labour for improving birth outcomes 

Pharmacological treatment for psychotic depression 

Phosphodiesterase 4 inhibitors for chronic obstructive pulmonary disease 

Pimozide for schizophrenia or related psychoses

Platelet glycoprotein IIb/IIIa blockers during percutaneous coronary intervention and as the initial medical treatment of non-ST segment elevation acute coronary syndromes 

Postnatal parental education for optimizing infant general health and parent-infant relationships 

Post-operative radiotherapy for ductal carcinoma in situ of the breast

Progestin-only pills for contraception 

Prophylactic antibiotics for penetrating abdominal trauma

Prophylactic antibiotics for preventing Gram positive infections associated with long-term central venous catheters in oncology patients 

Quetiapine versus other atypical antipsychotics for schizophrenia 

Routine scale and polish for periodontal health in adults 

Screening programmes for the early detection and prevention of oral cancer

Systemic antimicrobial prophylaxis for percutaneous endoscopic gastrostomy

Targeting intensive glycaemic control versus targeting conventional glycaemic control for type 2 diabetes mellitus 

Thyrotropin-releasing hormone added to corticosteroids for women at risk of preterm birth for preventing neonatal respiratory disease

Topical cystic fibrosis transmembrane conductance regulator gene replacement for cystic fibrosis-related lung disease 

Treatment for femoral pseudoaneurysms 

Vitamin C for preventing and treating tetanus

Withdrawn Reviews

Benzodiazepines and related drugs for insomnia in palliative care  (Withdrawn)

Epidural blood patching for preventing and treating post-dural puncture headache (Withdrawn)

Interventions to promote the wearing of hearing protection (Withdrawn) 

Non-pharmacological interventions for breathlessness in advanced stages of malignant and non-malignant diseases  (Withdrawn)

Oxygen therapy for dyspnoea in adults  (Withdrawn)

Pleurodesis for malignant pleural effusions  (Withdrawn)

Prophylactic antibiotic therapy for chronic bronchitis  (Withdrawn)

Radiotherapy for the palliation of painful bone metastases  (Withdrawn)

Single dose dipyrone for acute postoperative pain (Withdrawn)

Spinal cord stimulation for chronic pain  (Withdrawn)

Touch therapies for pain relief in adults  (Withdrawn)



Should The Cochrane Collaboration be producing reviews of efficiency?

Mike Drummond, Ian Shemilt & Luke Vale, on behalf of the Campbell and Cochrane Economic Methods Group

Cochrane Database Syst Rev. 2013 October 24;10:ED000071





Metin Gülmezoglu, João Paulo Souza, Jitendra Khanna, Guillermo Carroli, Justus Hofmeyr, Jean-José Wolomby-Molondo, Suneeta Mittal, Pisake Lumbiganon & Linan Cheng

Cochrane Database Syst Rev. 2013 October 23;10:ED000070



Manu Mathew, Anna Joseph, James Heilman & Prathap Tharyan

Cochrane Database Syst Rev. 2013 October 22;10:ED000069



Helen Handoll, Nigel Hanchard, Mario Lenza & Rachelle Buchbinder

Cochrane Database Syst Rev. 2013 October 7;10:ED000068




New Reviews

Addition of anti-leukotriene agents to inhaled corticosteroids in children with persistent asthma

Anti-vascular endothelial growth factor for neovascular glaucoma

Anticonvulsants for fibromyalgia 

Aromatase inhibitors for uterine fibroids

Atypical antipsychotics for psychosis in adolescents 

Barriers and facilitators to the implementation of lay health worker programmes to improve access to maternal and child health: qualitative evidence synthesis 

Beclometasone for chronic obstructive pulmonary disease

Behavioural therapies versus other psychological therapies for depression

Behavioral interventions for improving condom use for dual protection 

Beta2-agonists for exercise-induced asthma

Blood pressure targets for hypertension in people with diabetes mellitus

Combined and alternating paracetamol and ibuprofen therapy for febrile children

Dietary supplements for preventing postnatal depression 

Early and late renal adverse effects after potentially nephrotoxic treatment for childhood cancer 

Early versus delayed post-operative bathing or showering to prevent wound complications

Endovenous thermal ablation for healing venous ulcers and preventing recurrence 

Enhanced care by generalists for functional somatic symptoms and disorders in primary care 

Influenza vaccines in immunosuppressed adults with cancer

Integrated disease management interventions for patients with chronic obstructive pulmonary disease

Interventions for the treatment of Paget's disease of the vulva

Lactose avoidance for young children with acute diarrhoea

Laparoscopically assisted radical vaginal hysterectomy versus radical abdominal hysterectomy for the treatment of early cervical cancer

Long-acting beta2-agonists for chronic obstructive pulmonary disease 

Manual small incision cataract surgery (MSICS) with posterior chamber intraocular lens versus phacoemulsification with posterior chamber intraocular lens for age-related cataract

Micronutrient supplementation for children with HIV infection

Microwave coagulation for liver metastases

Naproxen with or without an antiemetic for acute migraine headaches in adults 

Narrow-band ultraviolet B phototherapy versus broad-band ultraviolet B or psoralen-ultraviolet A photochemotherapy for psoriasis 

Negative pressure wound therapy for treating foot wounds in people with diabetes mellitus 

Optimal time for initiating antiretroviral therapy (ART) in HIV-infected, treatment-naive children aged 2 to 5 years old

Orthodontic treatment for distalising upper first molars in children and adolescents 

Pegylated liposomal doxorubicin for first-line treatment of epithelial ovarian cancer

Pharmacological treatment for pain in Guillain-Barré syndrome

Sumatriptan plus naproxen for acute migraine attacks in adults 

'Third wave' cognitive and behavioural therapies versus other psychological therapies for depression

'Third wave' cognitive and behavioural therapies versus treatment as usual for depression 

Thymectomy for non-thymomatous myasthenia gravis

Transdermal fentanyl for cancer pain 

Vitamin C for asthma and exercise-induced bronchoconstriction 

Vocational rehabilitation for enhancing return-to-work in workers with traumatic upper limb injuries

Wound drainage after axillary dissection for carcinoma of the breast 

Updated Reviews

Antibiotics for preventing meningococcal infections

Antibiotics for the prophylaxis of bacterial endocarditis in dentistry

Artemisinin-based combination therapy for treating uncomplicated Plasmodium vivax malaria

Breathing exercises for adults with asthma

Chinese herbal medicine for diabetic peripheral neuropathy

Comparative efficacy of epidural, subarachnoid, and intracerebroventricular opioids in patients with pain due to cancer (Withdrawn)

Corticosteroids for viral myocarditis 

Dance therapy for schizophrenia

Hyaluronate for temporomandibular joint disorders (Withdrawn) 

Hydromorphone for acute and chronic pain (Withdrawn) 

In vitro maturation in subfertile women with polycystic ovarian syndrome undergoing assisted reproduction

Intrauterine insemination versus fallopian tube sperm perfusion for non-tubal infertility

Maintenance therapy with calcium channel blockers for preventing preterm birth after threatened preterm labour

Maintenance therapy with oxytocin antagonists for inhibiting preterm birth after threatened preterm labour

Maternal positions and mobility during frist stage labour

Music for pain relief (Withdrawn)

Nebulized epinephrine for croup in children

Non-corticosteroid immunosuppressive medications for steroid-sensitive nephrotic syndrome in children

Non-pharmacological interventions for preventing venous insufficiency in a standing worker population 

Opioid switching to improve pain relief and drug tolerability (Withdrawn)

Opioids for the management of breakthrough pain in cancer patients

Oral anti-pseudomonal antibiotics for cystic fibrosis

Oral versus intravenous antibiotic treatment for febrile neutropenia in cancer patients

Pelargonium sidoides extract for treating acute respiratory tract infections

Physical fitness training for stroke patients

Platelet glycoprotein IIb/IIIa blockers during percutaneous coronary intervention and as the initial medical treatment of non-ST segment elevation acute coronary syndromes 

Primaquine for preventing relapse in people with Plasmodium vivax malaria treated with chloroquine

Primary closure versus delayed closure for non bite traumatic wounds within 24 hours post injury

Progestogen for preventing miscarriage

Prophylactic oxytocin for the third stage of labour to prevent postpartum haemorrhage

Psychological interventions for depression in adolescent and adult congenital heart disease

Psychological interventions for needle-related procedural pain and distress in children and adolescents

Psychosocial interventions for people with both severe mental illness and substance misuse 

Psychosocial interventions for supporting women to stop smoking in pregnancy

Reading aids for adults with low vision 

Retention versus sacrifice of the posterior cruciate ligament in total knee arthroplasty for treating osteoarthritis

Single dose oral celecoxib for acute postoperative pain in adults

Single dose oral dexibuprofen [S(+)-ibuprofen] for acute postoperative pain in adults 

Strategies for partner notification for sexually transmitted infections, including HIV

Strategies to improve adherence and acceptability of hormonal methods of contraception

Supplemental perioperative steroids for surgical patients with adrenal insufficiency (Withdrawn) 

Surgical interventions for the early management of Bell's palsy

Topical lidocaine for the treatment of postherpetic neuralgia (Withdrawn) 

Treatment of vaginal bleeding irregularities induced by progestin only contraceptives 

Urodynamic studies for management of urinary incontinence in children and adults

User-held personalised information for routine care of people with severe mental illness 

Valproic acid, valproate and divalproex in the maintenance treatment of bipolar disorder 

Vitamin C supplementation for asthma (Withdrawn) 






Philipp Dahm, Molly Neuberger & Dragan Ilic

Cochrane Database Syst Rev. 2013 September 16;9:ED000067


New Reviews

Analgesia for forceps delivery 

Anti-IgE therapy for allergic bronchopulmonary aspergillosis in people with cystic fibrosis

Chest physiotherapy for pneumonia in children

Chinese herbal medicine for atopic eczema

Cognitive behavioural therapies for fibromyalgia

Combined oestrogen and progesterone for preventing miscarriage 

Early versus delayed dressing removal after primary closure of clean and clean-contaminated surgical wounds

Early versus delayed laparoscopic cholecystectomy for acute gallstone pancreatitis

Efficacy of psychostimulant drugs for amphetamine abuse or dependence 

Enzyme replacement therapy with laronidase (Aldurazyme) for treating mucopolysaccharidosis type I 

Face-to-face interventions for promoting physical activity 

Face-to-face versus remote and web 2.0 interventions for promoting physical activity

Flexible sigmoidoscopy versus faecal occult blood testing for colorectal cancer screening in asymptomatic individuals 

Interventions for helping people adhere to compression treatments for venous leg ulceration

Interventions for managing relapse of the lower front teeth after orthodontic treatment

Interventions for promoting habitual exercise in people living with and beyond cancer

Interventions for the reduction of prescribed opioid use in chronic non-cancer pain

Magnetic resonance imaging, magnetic resonance arthrography and ultrasonography for assessing rotator cuff tears in people with shoulder pain for whom surgery is being considered

Media-delivered cognitive behavioural therapy and behavioural therapy (self-help) for anxiety disorders in adults

Orthodontic treatment for prominent lower front teeth (Class III malocclusion) in children   

Perioperative nutrition interventions for women with ovarian cancer

Post-surgical chemotherapy versus surgery alone for resectable gastric cancer 

Remote and web 2.0 interventions for promoting physical activity 

Search strategies to identify diagnostic accuracy studies in MEDLINE and EMBASE

Secondary suturing compared to non-suturing for broken down perineal wounds following childbirth

Supported employment for adults with severe mental illness

Supraglottic airway devices versus tracheal intubation for airway management during general anaesthesia in obese patients

Surveillance of gastric intestinal metaplasia for the prevention of gastric cancer 

Systemic treatments for the prevention of venous thrombo-embolic events in paediatric cancer patients with tunnelled central venous catheters

Tiotropium versus ipratropium bromide for chronic obstructive pulmonary disease

Titrated oral misoprostol for augmenting labour to improve maternal and neonatal outcomes


Updated Reviews

Active chest compression-decompression for cardiopulmonary resuscitation

Antibiotics for treating chronic osteomyelitis in adults

Beta blockers for peripheral arterial disease

Botulinum toxin for masseter hypertrophy

Caesarean section versus vaginal delivery for preterm birth in singletons

Cervico-thoracic or lumbar sympathectomy for neuropathic pain and complex regional pain syndrome

Chest physiotherapy compared to no chest physiotherapy for cystic fibrosis

Chinese herbal medicine for atopic eczema (Withdrawn)

D-Penicillamine for preventing retinopathy of prematurity in preterm infants

Debridement for surgical wounds

Exercise for depression

HMG CoA reductase inhibitors (statins) for dialysis patients

Holding chambers (spacers) versus nebulisers for beta-agonist treatment of acute asthma

Interventions for the management of dry mouth: non-pharmacological interventions

Intravenous immunoglobulin for treating sepsis, sever sepsis and septic shock

Inspiratory muscle training for asthma

Interspace/interdental brushes for oral hygiene in orthodontic patients with fixed appliances (Withdrawn)

Interventions for protecting renal function in the perioperative period

Interventions for replacing missing teeth: dental implants in zygomatic bone for the rehabilitation of the severely deficient edentulous maxilla

Interventions for replacing missing teeth: hyperbaric oxygen therapy for irradiated patients who require dental implants 

Optimal timing for intravascular administration set replacement

Oral rinses, mouthwashes and sprays for improving recovery following tonsillectomy

Organised inpatient (stroke unit) care for stroke

Package of care for active management in labour for reducing caesarean section rates in low-risk women 

Paracervical local anaesthesia for cervical dilatation and uterine intervention 

Perioperative fluid volume optimization following proximal femoral fracture

Physical training for asthma

Physiotherapy versus placebo or no intervention in Parkinson's disease

Reduced dietary salt for the prevention of cardiovascular disease (Withdrawn)

Routine abdominal drainage versus no abdominal drainage for uncomplicated laparoscopic cholecystectomy 

Spermicide used alone for contraception

Silicone gel sheeting for preventing and treating hypertrophic and keloid scars

Surgical versus endoscopic treatment of bile duct stones

Sweet potato for type 2 diabetes mellitus 

Thoracic stent graft versus surgery for thoracic aneurysm


Issue 8 August 2013 (COMPLETE)


Mosquito larval source management: Evaluating evidence in the context of practice and policy

Robert D. Newman, Abraham Mnzava & Zsofia Szilagyi

Cochrane Database Syst Rev. 2013 August 29;8:ED000066


Oxygen therapy in acute myocardial infarction – good or bad?

Pascal Meier, Shah Ebrahim, Catherine M. Otto & Juan P. Casas

Cochrane Database Syst Rev. 2013 August 21;8:ED000065



Ale Algra

Cochrane Database Syst Rev. 2013 August 8;8:ED000064

New Reviews

Aminophylline for bradyasystolic cardiac arrest in adults

Antibiotic prophylaxis for the prevention of methicillin-resistant Staphylococcus aureus (MRSA) related complications in surgical patients

Antibiotic therapy for the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections in surgical wounds

Antimicrobial therapy for chronic bacterial prostatitis

Antioxidants for female subfertility

Assisted reproductive technology: an overview of Cochrane Reviews

Autologous serum eye drops for dry eye 

Chemotherapy for thymic carcinoma and advanced thymoma in adults

Cisplatin versus carboplatin in combination with third-generation drugs for advanced non-small cell lung cancer

Dressings and topical agents for preventing pressure ulcers

Factor Xa inhibitors versus vitamin K antagonists for preventing cerebral or systemic embolism in patients with atrial fibrillation

Fibrinogen concentrate in bleeding patients 

Heparin for assisted reproduction

Herbal medicines for fatty liver diseases

In-work tax credits for families and their impact on health status in adults

Interventions for erythropoietin-resistant anaemia in dialysis patients

Interventions for the management of dry mouth: non-pharmacological interventions  

Interventions to improve water quality and supply, sanitation and hygiene practices, and their effects on the nutritional status of children

Laquinimod for multiple sclerosis

'Mediterranean' dietary pattern for the primary prevention of cardiovascular disease

Mosquito larval source management for controlling malaria 

Natural cycle in vitro fertilisation (IVF) for subfertile couples 

Nitrates for acute heart failure syndromes

Non-pharmacological interventions for fatigue in rheumatoid arthritis

Nonoperative treatment for lumbar spinal stenosis with neurogenic claudication 

Occupational safety and health enforcement tools for preventing occupational diseases and injuries 

Oral hygiene care for critically ill patients to prevent ventilator-associated pneumonia

Percutaneous cholecystostomy for high-risk surgical patients with acute calculous cholecystitis

Relaxin for preventing preterm birth

Risk of ovarian cancer in women treated with ovarian stimulating drugs for infertility

Smoking cessation interventions for smokers with current or past depression

Subpial transection surgery for epilepsy

Topiramate for neuropathic pain and fibromyalgia in adults 

Transabdominal amnioinfusion for improving fetal outcomes after oligohydramnios secondary to preterm prelabour rupture of membranes before 26 weeks

Tripterygium wilfordii Hook F (a traditional Chinese medicine) for primary nephrotic syndrome


Updated Reviews

20 mcg versus >20 mcg estrogen combined oral contraceptives for contraception

Abdominal lift for laparoscopic cholecystectomy 

Acupuncture for induction of labour

Antifibrinolytic therapy for aneurysmal subarachnoid haemorrhage 

Allogeneic stem cell transplantation versus conventional therapy for advanced primary cutaneous T-cell lymphoma 

Antibiotics for preventing complications in children with measles

Antipsychotics for acute and chronic pain in adults 

Autologous hematopoietic stem cell transplantation following high dose chemotherapy for non-rhabdomyosarcoma soft tissue sarcomas 

Combined corticosteroid and long-acting beta2-agonist in one inhaler versus inhaled corticosteroids alone for chronic obstructive pulmonary disease

Combined inhaled anticholinergics and short-acting beta2-agonists for initial treatment of acute asthma in children

Cryoplasty for peripheral arterial disease

Cyanoacrylate microbial sealants for skin preparation prior to surgery

Cycled light in the intensive care unit for preterm and low birth weight infants

Desferrioxamine mesylate for managing transfusional iron overload in people with transfusion-dependent thalassaemia 

Different corticosteroids and regimens for accelerating fetal lung maturation for women at risk of preterm birth 

Driving assessment for maintaining mobility and safety in drivers with dementia 

Early amniotomy and early oxytocin for prevention of, or therapy for, delay in first stage spontaneous labour compared with routine care 

Early light reduction for preventing retinopathy of prematurity in very low birth weight infants

Electrotherapy for neck pain

Endometrial resection and ablation techniques for heavy menstrual bleeding 

Fundoplication versus postoperative medication for gastro-oesophageal reflux in children with neurological impairment undergoing gastrostomy 

Gonadotrophins for idiopathic male factor subfertility

Granulocyte-colony stimulating factors as adjunctive therapy for diabetic foot infections

Haloperidol dose for the acute phase of schizophrenia 

Herbal medicines for viral myocarditis

High-dose chemotherapy and autologous haematopoietic stem cell rescue for children with high-risk neuroblastoma

Hydrocolloid dressings for healing diabetic foot ulcers

Influenza vaccination in children being treated with chemotherapy for cancer

Infraclavicular brachial plexus block for regional anaesthesia of the lower arm 

Internal versus external tocodynamometry during induced or augmented labour

Interventions for preventing and treating pelvic and back pain in pregnancy

Local anaesthetic sympathetic blockade for complex regional pain syndrome

Maternal positions and mobility during first stage labour

Midwife-led continuity models versus other models of care for childbearing women

Miniports versus standard ports for laparoscopic cholecystectomy

Newborn screening for homocystinuria

Nursing interventions for smoking cessation

Opioids compared to placebo or other treatments for chronic low-back pain 

Opioids for neuropathic pain 

Oral deferiprone for iron chelation in people with thalassaemia 

Oxygen therapy for acute myocardial infarction

Pharmacological treatment for Kleine-Levin syndrome

Phenytoin versus valproate monotherapy for partial onset seizures and generalised onset tonic-clonic seizures

Physical conditioning as part of a return to work strategy to reduce sickness absence for workers with back pain 

Postnatal phenobarbital for the prevention of intraventricular haemorrhage in preterm infants

Posture and fluids for preventing post-dural puncture headache (Withdrawn)

Pre-admission antibiotics for suspected cases of meningococcal disease

Probiotics for treating persistent diarrhoea in children

Relapse prevention interventions for smoking cessation

Restricting oral fluid and food intake during labour

Selective serotonin reuptake inhibitors (SSRIs) for autism spectrum disorders (ASD)

Single, double or multiple-injection techniques for non-ultrasound guided axillary brachial plexus block in adults undergoing surgery of the lower arm

Supervised exercise therapy versus non-supervised exercise therapy for intermittent claudication

Telephone counselling for smoking cessation

Theory-based interventions for contraception

Tobacco cessation interventions for young people

Traction for low-back pain with or without sciatica

Virtual reality training for surgical trainees in laparoscopic surgery

Vitamin C for preventing and treating pneumonia  


Table Of Contents - Cochrane database of Systematic reviews

ISSUE 7 JULY 2013 (COMplete)


Folic acid supplementation for rheumatoid arthritis patients on methotrexate: the good gets better

Jasvinder Singh

Cochrane Database Syst Rev. 2013 July 24;7:ED000063

calling time on intravenous immunoglobulin for preterm infants?

Roger Soll

Cochrane Database Syst Rev. 2013 July 19;7:ED000062

New Reviews

Acetaminophen (paracetamol) for the common cold in adults

Acupuncture for menopausal hot flushes

Acupuncture for stress urinary incontinence in adults

Anthracycline-containing regimens for treatment of follicular lymphoma in adults

Antifibrinolytics (lysine analogues) for the prevention of bleeding in patients with haematological disorders

CHIVA method for the treatment of chronic venous insufficiency

Early versus late administration of amino acids in preterm infants receiving parenteral nutrition

Exercise training undertaken by people within 12 months of lung resection for non-small cell lung cancer

First-line allogeneic hematopoietic stem cell transplantation of HLA-matched sibling donors compared with first-line ciclosporin and/or antithymocyte or antilymphocyte globulin for acquired severe aplastic anemia

Intermittent drug techniques for schizophrenia

Interventions for implementation of thromboprophylaxis in hospitalized medical and surgical patients at risk for venous thromboembolism

Interventions for supporting pregnant women's decision-making about mode of birth after a caesarean

Interventions to encourage uptake of cancer screening for people with severe mental illness

Interventions to promote informed consent for patients undergoing surgical and other invasive healthcare procedures

Leukodepletion for patients undergoing heart valve surgery

Linezolid versus vancomycin for skin and soft tissue infections

Low molecular weight heparin for prevention of microvascular occlusion in digital replantation

Mass media interventions for reducing mental health-related stigma

Opioids for acute pancreatitis pain

Padma 28 for intermittent claudication

Pegylated liposomal doxorubicin for relapsed epithelial ovarian cancer

Perioperative antibiotics for prevention of acute endophthalmitis after cataract surgery

Perioperative statin therapy for improving outcomes during and after noncardiac vascular surgery

Peritoneal closure versus no peritoneal closure for patients undergoing non-obstetric abdominal operations

Pharmacological agents for preventing morbidity associated with the haemodynamic response to tracheal intubation

Pharmacotherapy for the prevention of chronic pain after surgery in adults

Protocolized versus non-protocolized weaning for reducing the duration of invasive mechanical ventilation in critically ill paediatric patients

Postpartum misoprostol for preventing maternal mortality and morbidity

Posture and fluids for preventing post-dural puncture headache

Psychoanalytic/psychodynamic psychotherapy for children and adolescents who have been sexually abused

Psychosocial interventions for patients with head and neck cancer

Regular (ICSI) versus ultra-high magnification (IMSI) sperm selection for assisted reproduction

Respiratory muscle training for cervical spinal cord injury

Rifamycins (rifampicin, rifabutin and rifapentine) compared to isoniazid for preventing tuberculosis in HIV-negative people at risk of active TB

Routine vaginal examinations for assessing progress of labour to improve outcomes for women and babies at term

Schedules for home visits in the early postpartum period

Telephone support for women during pregnancy and the first six weeks postpartum

Topical application of tranexamic acid for the reduction of bleeding

Vaccines for preventing enterotoxigenic Escherichia coli (ETEC) diarrhoea

Warfarin initiation nomograms for venous thromboembolism

Xuebijing for paraquat poisoning


Updated Reviews

Acupuncture and assisted reproductive technology

Adjustable versus non-adjustable sutures for strabismus

Antibiotic prophylaxis for short-term catheter bladder drainage in adults

Antiplatelet and anticoagulation for patients with prosthetic heart valves

Antithrombotic therapy for improving maternal or infant health outcomes in women considered at risk of placental dysfunction

Castor oil, bath and/or enema for cervical priming and induction of labour

Cognitive rehabilitation for spatial neglect following stroke

Day-surgery versus overnight stay surgery for laparoscopic cholecystectomy

Diet or exercise, or both, for weight reduction in women after childbirth

Drugs for treatment of very high blood pressure during pregnancy

Effect of partogram use on outcomes for women in spontaneous labour at term

Effect of timing of umbilical cord clamping of term infants on maternal and neonatal outcomes

Electromechanical-assisted training for walking after stroke

Emergency ultrasound-based algorithms for diagnosing blunt abdominal trauma

Enemas during labour

Fluoride varnishes for preventing dental caries in children and adolescents

Fluoxetine versus other types of pharmacotherapy for depression

Fluphenazine (oral) versus placebo for schizophrenia

Gabapentin add-on for drug-resistant partial epilepsy

Gastrostomy feeding versus oral feeding alone for children with cerebral palsy

High-dose versus low-dose oxytocin for augmentation of delayed labour

Homocysteine lowering interventions for peripheral arterial disease and bypass grafts

Hydrogel dressings for healing diabetic foot ulcers

Hydroxyethyl starch (HES) versus other fluid therapies: effects on kidney function

Influenza vaccination for healthcare workers who care for people aged 60 or older living in long-term care institutions

Insulin and oral agents for managing cystic fibrosis-related diabetes

Internet-based interventions for smoking cessation

Interventionist versus expectant care for severe pre-eclampsia between 24 and 34 weeks' gestation

Interventions for infantile esotropia

Interventions for replacing missing teeth: antibiotics at dental implant placement to prevent complications

Interventions for the management of mandibular fractures

Interventions (other than pharmacological, psychosocial or psychological) for treating antenatal depression

Intravenous immunoglobulin for preventing infection in preterm and/or low birth weight infants

Intravenous immunoglobulin for suspected or proven infection in neonates

Intravenous versus inhalation anaesthesia for one-lung ventilation

Nebulised hypertonic saline solution for acute bronchiolitis in infants

Nebulized and oral thiol derivatives for pulmonary disease in cystic fibrosis

Neuraxial anaesthesia for lower-limb revascularization

Nonsteroidal anti-inflammatory drugs and perioperative bleeding in paediatric tonsillectomy

Number of embryos for transfer following in vitro fertilisation or intra-cytoplasmic sperm injection

Omega-3 fatty acids for intermittent claudication

Once versus twice daily low molecular weight heparin for the initial treatment of venous thromboembolism

Opioids for the palliation of breathlessness in advanced disease and terminal illness (Withdrawn)

Oral morphine for cancer pain

Oxygen therapy for cystic fibrosis

Oxytocin augmentation of labour in women with epidural analgesia for reducing operative deliveries

Partial liquid ventilation for preventing death and morbidity in adults with acute lung injury and acute respiratory distress syndrome

Posture and fluids for preventing post-dural puncture headache (Withdrawn)

Prenatal administration of progesterone for preventing preterm birth in women considered to be at risk of preterm birth

Progestin-only contraceptives: effects on weight

Simple behavioural interventions for nocturnal enuresis in children

Steroids for idiopathic sudden sensorineural hearing loss

Strength training and aerobic exercise training for muscle disease

Surgery for faecal incontinence in adults

Thiamine for prevention and treatment of Wernicke-Korsakoff Syndrome in people who abuse alcohol

Treatment of vaginal bleeding irregularities induced by progestin only contraceptives

Triptans for acute cluster headache

Uterine massage for preventing postpartum haemorrhage

Weighted vaginal cones for urinary incontinence


ISSUe 6 June 2013 (COMPLETE)


waiting for the evidence from ongoing trials: the role of surgery for treating clavicle fractures

Helen Handoll & Mario Lenza

Cochrane Database Syst Rev. 2013 June 12;6:ED000061

New Reviews

Abacavir-based triple nucleoside regimens for maintenance therapy in patients with HIV

Adenosine and verapamil for no-reflow during primary percutaneous coronary intervention in people with acute myocardial infarction

Antibiotic and other lock treatments for tunnelled central venous catheter-related infections in children with cancer

Antibiotic prophylaxis for preventing burn wound infection

Antiepileptic drugs for the primary and secondary prevention of seizures after subarachnoid haemorrhage

Antiepileptics other than gabapentin, pregabalin, topiramate, and valproate for the prophylaxis of episodic migraine in adults

Automated versus non-automated weaning for reducing the duration of mechanical ventilation for critically ill adults and children

Chinese herbal medicines for hypertriglyceridaemia

Chinese medicinal herbs for cholelithiasis

Comparison of different regimens of proton pump inhibitors for acute peptic ulcer bleeding

Conservative interventions for treating exercise-related musculotendinous, ligamentous and osseous groin pain

Cryotherapy for liver metastases

Decentralising HIV treatment in lower- and middle-income countries

Deliberate hypotension with propofol under anaesthesia for functional endoscopic sinus surgery (FESS)

Educational and behavioural interventions for anticoagulant therapy in patients with atrial fibrillation

Educational and skills-based interventions for preventing relationship and dating violence in adolescents and young adults

Effectiveness and cost-effectiveness of home palliative care services for adults with advanced illness and their caregivers

Elective preterm birth for fetal gastroschisis

Electrical stimulation with non-implanted electrodes for urinary incontinence in men

Environmental and behavioural interventions for reducing physical activity limitation in community-dwelling visually impaired older people

Epidural analgesia for cardiac surgery

Gabapentin or pregabalin for the prophylaxis of episodic migraine in adults

Green and black tea for the primary prevention of cardiovascular disease

High-dose chemotherapy followed by autologous stem cell transplantation for patients with relapsed/refractory Hodgkin lymphoma

High versus low positive end-expiratory pressure (PEEP) levels for mechanically ventilated adult patients with acute lung injury and acute respiratory distress syndrome

Hormone replacement therapy for women with type 1 diabetes mellitus

Hormone therapy for sexual function in perimenopausal and postmenopausal women

Immunomodulators and immunosuppressants for multiple sclerosis: a network meta-analysis

Immunomodulatory interventions for focal epilepsy syndromes

Increased consumption of fruit and vegetables for the primary prevention of cardiovascular diseases

Interconception care for women with a history of gestational diabetes for improving maternal and infant outcomes

Interferon after surgery for women with advanced (Stage II-IV) epithelial ovarian cancer

Interferon alpha for the adjuvant treatment of cutaneous melanoma

Interventions for cutaneous Bowen's disease

Interventions for promoting participation in shared decision-making for children with cancer

Interventions for the restorative care of amelogenesis imperfecta in children and adolescents

Intravenous fluids for reducing the duration of labour in low risk nulliparous women

Isoflavones for hypercholesterolaemia in adults

Levonorgestrel-releasing intrauterine system for atypical endometrial hyperplasia

Low-molecular-weight heparins for managing vaso-occlusive crises in people with sickle cell disease

Magnesium for alcohol withdrawal

Media campaigns for the prevention of illicit drug use in young people

Metered dose inhalers versus nebulizers for aerosol bronchodilator delivery for adult patients receiving mechanical ventilation in critical care units

Multidisciplinary rehabilitation following botulinum toxin and other focal intramuscular treatment for post-stroke spasticity

Music interventions for preoperative anxiety

Occupational therapy for care home residents with stroke

Pharmacological interventions for pruritus in adult palliative care patients

QTc interval screening for cardiac risk in methadone treatment of opioid dependence

Ready-to-use therapeutic food for home-based treatment of severe acute malnutrition in children from six months to five years of age

Recombinant growth hormone therapy for cystic fibrosis in children and young adults

Rehabilitation following carpal tunnel release

Single dose oral ibuprofen plus oxycodone for acute postoperative pain in adults

Single dose oral ibuprofen plus paracetamol (acetaminophen) for acute postoperative pain

Slow-release oral morphine as maintenance therapy for opioid dependence

Specially formulated foods for treating children with moderate acute malnutrition in low- and middle-income countries

Stents for the prevention of pancreatic fistula following pancreaticoduodenectomy 

Supplemental oxygen for caesarean section during regional anaesthesia

Surgical resection versus liver transplant for patients with hepatocellular carcinoma

Surgical versus conservative interventions for treating fractures of the middle third of the clavicle

Topiramate for the prophylaxis of episodic migraine in adults

Transcranial direct current stimulation (tDCS) for improving aphasia in patients after stroke

Vaccines for the common cold

Valproate (valproic acid or sodium valproate or a combination of the two) for the prophylaxis of episodic migraine in adults

Vitrectomy with internal limiting membrane (ILM) peeling versus vitrectomy with no peeling for idiopathic full-thickness macular hole (FTMH)

Zinc supplements for treating thalassaemia and sickle cell disease


Updated Reviews

Alginate dressings for healing diabetic foot ulcers

Amniotomy for shortening spontaneous labour

Antibiotic adjuvant therapy for pulmonary infection in cystic fibrosis

Antibiotics for community-acquired pneumonia in children

Antibiotics for the common cold and acute purulent rhinitis

Anticonvulsants for preventing seizures in patients with chronic subdural haematoma

Antispasmodics for labour

Aromatherapy and massage for symptom relief in patients with cancer (Withdrawn)

Beta-lactam versus beta-lactam-aminoglycoside combination therapy in cancer patients with neutropenia

Chemotherapy for second-stage Human African trypanosomiasis

Chinese herbal medicine Huangqi type formulations for nephrotic syndrome

Cognitive behavioural therapy for anxiety disorders in children and adolescents

Cognitive training and cognitive rehabilitation for mild to moderate Alzheimer's disease and vascular dementia

Colony stimulating factors (including erythropoietin, granulocyte colony stimulating factor and analogues) for stroke

Corticosteroids for acute bacterial meningitis

Creatine for treating muscle disorders

Dehumidifiers for chronic asthma

Drug therapy for pain in amyotrophic lateral sclerosis or motor neuron disease

Drug treatment for faecal incontinence in adults

Early versus delayed laparoscopic cholecystectomy for people with acute cholecystitis

Fluoroquinolones for treating tuberculosis (presumed drug-sensitive)

Foam dressings for healing diabetic foot ulcers

Furosemide for transient tachypnoea of the newborn

Ginkgo biloba for intermittent claudication

Glucocorticoids for acute viral bronchiolitis in infants and young children

Heated, humidified air for the common cold

Immunomodulatory treatment other than corticosteroids, immunoglobulin and plasma exchange for chronic inflammatory demyelinating polyradiculoneuropathy

Interventions for treating cholestasis in pregnancy

Intranasal ipratropium bromide for the common cold

Iron therapy for improving psychomotor development and cognitive function in children under the age of three with iron deficiency anaemia

Maintenance chemotherapy for ovarian cancer

Mass media interventions for smoking cessation in adults

Nocturnal non-invasive positive pressure ventilation for stable chronic obstructive pulmonary disease

Non-steroidal anti-inflammatory drugs for the common cold

Opioid antagonists for smoking cessation

Opioids for the palliation of breathlessness in advanced disease and terminal illness (Withdrawn)

Oral non-steroidal anti-inflammatory drug therapy for lung disease in cystic fibrosis

Oral steroids for long-term use in cystic fibrosis

Oxytocin versus no treatment or delayed treatment for slow progress in the first stage of spontaneous labour

Palivizumab for prophylaxis against respiratory syncytial virus infection in children with cystic fibrosis

Pharmacological interventions for benzodiazepine mono-dependence management in outpatient settings

Psychological interventions for women with metastatic breast cancer

Psychotherapeutic interventions for cannabis abuse and/or dependence in outpatient settings (Withdrawn)

Regular treatment with formoterol and inhaled steroids for chronic asthma: serious adverse events

Retinoids for preventing the progression of cervical intra-epithelial neoplasia

Routine intraoperative ureteric stenting for kidney transplant recipients

Screening for breast cancer with mammography

Screening for lung cancer

Selective serotonin reuptake inhibitors for premenstrual syndrome

Specialist home-based nursing services for children with acute and chronic illnesses

Steroids for traumatic optic neuropathy

Support for mothers, fathers and families after perinatal death

Surgery for varicose veins: use of tourniquet

Surgery versus thrombolysis for initial management of acute limb ischaemia

Surgical versus non-surgical treatment for thoracolumbar burst fractures without neurological deficit

T-tube drainage versus primary closure after laparoscopic common bile duct exploration

T-tube drainage versus primary closure after open common bile duct exploration

Timing of dornase alfa inhalation for cystic fibrosis

Treatment of infantile spasms

Tricyclic drugs for depression in children and adolescents

Tyrosine supplementation for phenylketonuria

Vaccines for preventing infection with Pseudomonas aeruginosa in cystic fibrosis

Zinc for the common cold

ISSUE 5 May 2013 (Complete)


growing pain: striving for quality, relevance and applicability in cochrane reviews

Christopher Eccleston, Phil Wiffen, Sheena Derry & Andrew Moore

Cochrane Database Syst Rev. 2013 May 31;5:ED000059


Updated Reviews

what should the cochrane collaboration do about research that is, or might be, fraudulent?

John Carlisle, Nathan Pace, Jane Cracknell, Ann Møller, Tom Pedersen & Mathew Zacharias

Cochrane Database Syst Rev. 2013 May 31;5:ED000060.


New Reviews

Acupuncture for treating fibromyalgia

Airway clearance techniques for bronchiectasis

Antenatal immunoglobulin for fetal red blood cell alloimmunization

Antidepressants for polycystic ovary syndrome

Beta-blockers for preventing stroke recurrence

Breathing exercises for dysfunctional breathing/hyperventilation syndrome in adults

Continuous versus intermittent physiological monitoring for acute stroke

Early versus delayed mobilisation for aneurysmal subarachnoid haemorrhage

Electro-coagulation for liver metastases

Face to face interventions for informing or educating parents about early childhood vaccination

Fibrin glue instillation under skin flaps to prevent seroma-related morbidity following breast and axillary surgery

Flavonoids for treating venous leg ulcers

Flow-regulated versus differential pressure-regulated shunt valves for adult patients with normal pressure hydrocephalus

Foam dressings for venous leg ulcers

Granulocyte colony stimulating factor therapy for acute myocardial infarction

Home- or community-based programmes for treating malaria

Interventions for preventing falls in people after stroke

Laparoscopic versus open liver resection for benign and malignant hepatic lesions in adults

Lifestyle interventions for chronic gout

Pedicle screw fixation for traumatic fractures of the thoracic and lumbar spine

Percutaneous ethanol injection for liver metastases

Perioperative chemo(radio)therapy versus primary surgery for resectable adenocarcinoma of the stomach, gastroesophageal junction, and lower esophagus

Pharmacological interventions for smoking cessation: an overview and network meta-analysis

Primary school-based behavioural interventions for preventing caries

Probiotics for the prevention of Clostridium difficile-associated diarrhea in adults and children

Quetiapine versus typical antipsychotic medications for schizophrenia

Repetitive transcranial magnetic stimulation for improving function after stroke

Rituximab for thyroid-associated ophthalmopathy

Surgical interventions for treating radial head fractures in adults

Tacrolimus versus cyclosporin as primary immunosuppression for lung transplant recipients

Telephone delivered interventions for preventing HIV infection in HIV-negative persons

Telephone delivered interventions for reducing morbidity and mortality in people with HIV infection

Topical herbal therapies for treating osteoarthritis

Umbilical cord antiseptics for preventing sepsis and death among newborns

Use of hyperbaric versus isobaric bupivacaine for spinal anaesthesia for caesarean section

Xiongshao for restenosis after percutaneous coronary intervention in patients with coronary heart disease


Updated Reviews

Abdominal surgical incisions for caesarean section

Acetylcysteine and carbocysteine for acute upper and lower respiratory tract infections in paediatric patients without chronic broncho-pulmonary disease

Acupuncture for glaucoma

Autoinflation for hearing loss associated with otitis media with effusion

Cervical pessary for preventing preterm birth

Cognitive rehabilitation for attention deficits following stroke

Combination inhaled steroid and long-acting beta2-agonist versus tiotropium for chronic obstructive pulmonary disease

Continuous cardiotocography (CTG) as a form of electronic fetal monitoring (EFM) for fetal assessment during labour

Delayed introduction of progressive enteral feeds to prevent necrotising enterocolitis in very low birth weight infants

Driving assessment for maintaining mobility and safety in drivers with dementia

Drug therapy for obstructive sleep apnoea in adults

Duration of intravenous antibiotic therapy in people with cystic fibrosis

Enemas during labour

Etanercept for the treatment of rheumatoid arthritis

Fetal electrocardiogram (ECG) for fetal monitoring during labour

Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis

Hematopoietic stem cell transplantation for people with sickle cell disease

Hyperbaric oxygen as an adjuvant treatment for malignant otitis externa

Interventions for clinical and subclinical hypothyroidism pre-pregnancy and during pregnancy

Interventions for intermittent exotropia

Magnesium maintenance therapy for preventing preterm birth after threatened preterm labour

Mitoxantrone for multiple sclerosis

Non-invasive positive pressure ventilation (CPAP or bilevel NPPV) for cardiogenic pulmonary oedema

Non-steroidal anti-inflammatory drugs (NSAIDs) for treating lateral elbow pain in adults

Oxcarbazepine versus phenytoin monotherapy for epilepsy

Pharmacological treatment of depression in patients with a primary brain tumour

Physician advice for smoking cessation

Prophylactic antibiotics for transcervical intrauterine procedures

Repetitive transcranial magnetic stimulation for the treatment of amyotrophic lateral sclerosis or motor neuron disease

Rivastigmine for vascular cognitive impairment

Routine surgery in addition to chemotherapy for treating spinal tuberculosis

Short-term treatment with proton pump inhibitors, H2-receptor antagonists and prokinetics for gastro-oesophageal reflux disease-like symptoms and endoscopy negative reflux disease

Splenectomy versus conservative management for acute sequestration crises in people with sickle cell disease

Sponge versus diaphragm for contraception

Strategies for managing sexual dysfunction induced by antidepressant medication

Surgical versus non-surgical treatment for thoracolumbar burst fractures without neurological deficit

Therapeutic exercise for people with amyotrophic lateral sclerosis or motor neuron disease

Thrombolysis (different doses, routes of administration and agents) for acute ischaemic stroke

Vaccines for women to prevent neonatal tetanus



Assessing risk of bias in randomised clinical trials included in Cochrane Reviews: the why is easy, the how is a challenge

Asbjørn Hróbjartsson, Isabelle Boutron, Lucy Turner, Douglas G Altman & David Moher

Cochrane Database Syst Rev. 2013 Apr 30;4:ED000058

It's time for AllTrials registered and reported

Tracey Brown

Cochrane Database Syst Rev. 2013 Apr 30;4:ED000057.


Prevention of occupational diseases: implementing the evidence

Jos Verbeek, Thais Morata, Jani Ruotsalainen & Harri Vainio

Cochrane Database Syst Rev. 2013 Apr 22;4:ED000056.


New Reviews

Alginate dressings for venous leg ulcers

Biopsy versus resection for the management of low-grade gliomas

Brief co-incubation of sperm and oocytes for in vitro fertilization techniques

Cholesterol-reducing agents for aneurysmal subarachnoid haemorrhage

Cognitive rehabilitation for executive dysfunction in adults with stroke or other adult non-progressive acquired brain damage

Conservative interventions for treating diaphyseal fractures of the forearm bones in children

Corticosteroids for ocular toxoplasmosis

Deflation of gastric band balloon in pregnancy for improving outcomes

Desmopressin acetate (DDAVP) for preventing and treating acute bleeds during pregnancy in women with congenital bleeding disorders

Effectiveness of systematic screening for the detection of atrial fibrillation

Interventions for hiring, retaining and training district health systems managers in low- and middle-income countries

Interventions for the prevention of mycobacterium avium complex in adults and children with HIV

Interventions for the prevention of postoperative ear discharge after insertion of ventilation tubes (grommets) in children

Interventions for treating pain and disability in adults with complex regional pain syndrome

Interventions for treating traumatised permanent front teeth: luxated (dislodged) teeth

Intra-articular glucocorticoids for acute gout

Levomepromazine for nausea and vomiting in palliative care

Lung lavage for meconium aspiration syndrome in newborn infants

Mammography in combination with breast ultrasonography versus mammography for breast cancer screening in women at average risk

Monoclonal antibody for reducing the risk of respiratory syncytial virus infection in children

Multimedia educational interventions for consumers about prescribed and over-the-counter medications

Nebuliser systems for drug delivery in cystic fibrosis

Oral evening primrose oil and borage oil for eczema

Parent-mediated early intervention for young children with autism spectrum disorders (ASD)

Pharmacological interventions for self-injurious behaviour in adults with intellectual disabilities

Phyllanthus species versus antiviral drugs for chronic hepatitis B virus infection

Physical exercise training interventions for children and young adults during and after treatment for childhood cancer

Physical tests for shoulder impingements and local lesions of bursa, tendon or labrum that may accompany impingement

Rutosides for prevention of post-thrombotic syndrome

Rutosides for treatment of post-thrombotic syndrome

Screening women for intimate partner violence in healthcare settings

Sulphonylurea monotherapy for patients with type 2 diabetes mellitus

Swimming training for asthma in children and adolescents aged 18 years and under

The medical use of cannabis for reducing morbidity and mortality in patients with HIV/AIDS

Workplace pedometer interventions for increasing physical activity


Updated Reviews

Antenatal perineal massage for reducing perineal trauma

Antiplatelet drugs for polycythaemia vera and essential thrombocythaemia

Antiretroviral therapy for prevention of HIV transmission in HIV-discordant couples

Aspirin with or without an antiemetic for acute migraine headaches in adults

Azathioprine or 6-mercaptopurine for induction of remission in Crohn's disease

Benzodiazepines for psychosis-induced aggression or agitation

Chinese herbal medicines for induction of remission in advanced or late gastric cancer

Clinically-indicated replacement versus routine replacement of peripheral venous catheters

Combination formoterol and budesonide as maintenance and reliever therapy versus current best practice (including inhaled steroid maintenance), for chronic asthma in adults and children

Delayed antibiotics for respiratory infections

Diclofenac with or without an antiemetic for acute migraine headaches in adults

Different antibiotic treatments for group A streptococcal pharyngitis

Effect of longer-term modest salt reduction on blood pressure

Galantamine for vascular cognitive impairment

Garlic for peripheral arterial occlusive disease

Herbal preparations for uterine fibroids

Hormonal contraceptives for contraception in overweight or obese women

Hormone therapy for preventing cardiovascular disease in post-menopausal women

Ibuprofen for the treatment of patent ductus arteriosus in preterm and/or low birth weight infants

Ibuprofen with or without an antiemetic for acute migraine headaches in adults

Initial arch wires for tooth alignment during orthodontic treatment with fixed appliances

Interval debulking surgery for advanced epithelial ovarian cancer

Interventions for acute internal hordeolum

Interventions for improving adherence to ocular hypotensive therapy

Interventions to improve antibiotic prescribing practices for hospital inpatients

Massage for promoting mental and physical health in typically developing infants under the age of six months

Non-invasive ventilation for cystic fibrosis

Paracetamol (acetaminophen) with or without an antiemetic for acute migraine headaches in adults

Prevention and treatment of postpartum hypertension

Prophylactic systemic antifungal agents to prevent mortality and morbidity in very low birth weight infants

Prostanoids for intermittent claudication

'Scared Straight' and other juvenile awareness programs for preventing juvenile delinquency

School-based programmes for preventing smoking

Sequencing of chemotherapy and radiotherapy for early breast cancer

Skin patch and vaginal ring versus combined oral contraceptives for contraception

Somatostatin analogues for pancreatic surgery

Strategies for communicating contraceptive effectiveness

Surgical management of pelvic organ prolapse in women

Temozolomide for high grade glioma

Topical nasal steroids for treating nasal polyposis in people with cystic fibrosis

Transarterial (chemo)embolisation versus no intervention or placebo intervention for liver metastases

Treatment for superficial thrombophlebitis of the leg

Vitamin K supplementation for cystic fibrosis


ISSUE 3 March 2013


is the cochrane collaboration prepared for the era of patient-centred outcomes research?

Gerald Gartlehner & Maria Flamm

Cochrane Database Syst Rev. 2013 Mar 28;3:ED000054.


Cochrane reviews on neglected diseases: the case of cutaneous leishmaniasis

Urbà González

Cochrane Database Syst Rev. 2013 Mar 28;3:ED000055.


New Reviews

Angiotensin-converting enzyme (ACE) inhibitors for proteinuria and microalbuminuria in people with sickle cell disease

Anti-D administration after spontaneous miscarriage for preventing Rhesus alloimmunisation

Computer-based diabetes self-management interventions for adults with type 2 diabetes mellitus

Consumer-providers of care for adult clients of statutory mental health services

Continuous versus intermittent infusions of antibiotics for the treatment of severe acute infections

Different types of dietary advice for women with gestational diabetes mellitus

Effectiveness of the Valsalva Manoeuvre for reversion of supraventricular tachycardia

Folic acid supplementation during pregnancy for maternal health and pregnancy outcomes

FSH replaced by low-dose hCG in the late follicular phase versus continued FSH for assisted reproductive techniques

Helicopter emergency medical services for adults with major trauma

Human papillomavirus testing versus repeat cytology for triage of minor cytological cervical lesions

Inhaled corticosteroids for subacute and chronic cough in adults

Interventions to improve professional adherence to guidelines for prevention of device-related infections

Methods for administering subcutaneous heparin during pregnancy

Methods of term labour induction for women with a previous caesarean section

Multidimensional rehabilitation programmes for adult cancer survivors

Nidotherapy for people with schizophrenia

Non-pharmacological interventions for preventing secondary vascular events after stroke or transient ischemic attack

Osmotic therapies added to antibiotics for acute bacterial meningitis

Oxcarbazepine for neuropathic pain

Pathogen-reduced platelets for the prevention of bleeding

Single dose oral ibuprofen plus codeine for acute postoperative pain in adults

Stent graft types for endovascular repair of abdominal aortic aneurysms

Stent graft types for endovascular repair of thoracic aortic aneurysms

Subintimal angioplasty for chronic lower limb arterial occlusion

Sulthiame add-on therapy for epilepsy

The role of maintenance therapy in acute promyelocytic leukemia in the first complete remission

Thromboprophylaxis for trauma patients

Vasopressin and its analogues for the treatment of refractory hypotension in neonates

Withdrawal versus continuation of chronic antipsychotic drugs for behavioural and psychological symptoms in older people with dementia

Wound drainage after plastic and reconstructive surgery of the breast


Updated Reviews

Acupuncture for acute management and rehabilitation of traumatic brain injury

Antibiotics for acute laryngitis in adults

Antibiotics for brain abscesses in people with cyanotic congenital heart disease

Anti-TNF-? treatment for pelvic pain associated with endometriosis

Artichoke leaf extract for treating hypercholesterolaemia

Buflomedil for intermittent claudication

Calcium antagonists as an add-on therapy for drug-resistant epilepsy

Chinese medicinal herbs for influenza

Co-formulated abacavir-lamivudine-zidovudine for initial treatment of HIV infection and AIDS

Combination injectable contraceptives for contraception

Communication skills training for healthcare professionals working with people who have cancer

Corticosteroids for preventing postherpetic neuralgia

Damage control surgery for abdominal trauma

De-escalation of antimicrobial treatment for adults with sepsis, severe sepsis or septic shock

Dietary advice for reducing cardiovascular risk

Different functional treatment strategies for acute lateral ankle ligament injuries in adults (Withdrawn)

Dressings for superficial and partial thickness burns

Early trophic feeding versus enteral fasting for very preterm or very low birth weight infants

Exit interviews to reduce turnover amongst healthcare professionals

Ginkgo biloba for tinnitus

Hormonal versus non-hormonal contraceptives in women with diabetes mellitus type 1 and 2

Immobilisation and functional treatment for acute lateral ankle ligament injuries in adults (Withdrawn)

Infant position in neonates receiving mechanical ventilation

Interprofessional education: effects on professional practice and healthcare outcomes (update)

Interventions for replacing missing teeth: different times for loading dental implants

Interventions for treating wrist fractures in children (Withdrawn)

Lactase treated feeds to promote growth and feeding tolerance in preterm infants

Long-term effects of weight-reducing drugs in hypertensive patients

Maternal position during caesarean section for preventing maternal and neonatal complications

Mechanical ventilation for amyotrophic lateral sclerosis/motor neuron disease

Medical treatments for incomplete miscarriage

Megestrol acetate for treatment of anorexia-cachexia syndrome

Non-steroidal anti-inflammatory drugs for preventing heterotopic bone formation after hip arthroplasty (Withdrawn)

Operative caries management in adults and children

Parenting interventions for the prevention of unintentional injuries in childhood

Patient controlled intravenous opioid analgesia versus continuous epidural analgesia for pain after intra-abdominal surgery (Withdrawn)

Prebiotics in infants for prevention of allergy

Preoperative skin antiseptics for preventing surgical wound infections after clean surgery

Pre-treatment surgical para-aortic lymph node assessment in locally advanced cervical cancer

Prophylactic oral/topical non-absorbed antifungal agents to prevent invasive fungal infection in very low birth weight infants

Regular treatment with salmeterol and inhaled steroids for chronic asthma: serious adverse events

Sealants for preventing dental decay in the permanent teeth

Slow advancement of enteral feed volumes to prevent necrotising enterocolitis in very low birth weight infants

Surgical versus medical treatment with cyclooxygenase inhibitors for symptomatic patent ductus arteriosus in preterm infants

Therapeutic ultrasound for carpal tunnel syndrome

Topical treatments for chronic plaque psoriasis

Wound cleansing for pressure ulcers


ARCHIVES 2012 2013


preventing falls in older people: the story of a cochrane review

Lesley Gillespie

Cochrane Database Syst Rev. 2013 Feb 28;2:ED000053. 

A new search interface for the cochrane library

Ruth Foxlee & David Tovey

Cochrane Database Syst Rev. 2013 Feb 5;1:ED000052.

New Reviews

Antiepileptic drugs as prophylaxis for post-craniotomy seizures

Antiplatelet agents for chronic kidney disease

Chemotherapy and/or radiotherapy in combination with surgery for ovarian carcinosarcoma

Ciclesonide versus other inhaled corticosteroids for chronic asthma in children

Conservative interventions for treating hyperextension injuries of the proximal interphalangeal joints of the fingers

Dental extractions prior to radiotherapy to the jaws for reducing post-radiotherapy dental complications

Drug therapy for preventing post-dural puncture headache

Erythropoiesis-stimulating agents for anemia in rheumatoid arthritis

Gamma aminobutyric acid (GABA) receptor agonists for acute stroke

Housing improvements for health and associated socio-economic outcomes

Hydralazine in infants with persistent hypoxemic respiratory failure

Hypothermia for neuroprotection in children after cardiopulmonary arrest

Inhaled corticosteroids for subacute cough in children

Interventions for improving outcomes for pregnant women who have experienced genital cutting

Interventions for preventing or reducing domestic violence against pregnant women

Interventions for promoting reintegration and reducing harmful behaviour and lifestyles in street-connected children and young people

Interventions for supporting parents’ decisions about autopsy after stillbirth

Interventions for the eradication of methicillin-resistant Staphylococcus aureus (MRSA) in people with cystic fibrosis

Interventions to enhance adherence to dietary advice for preventing and managing chronic diseases in adults

Interventions to optimise prescribing for older people in care homes

Magnesium sulphate for women at term for neuroprotection of the fetus

Medication review in hospitalised patients to reduce morbidity and mortality

Minimally invasive versus open surgery for reversal of tubal sterilization

Morning versus evening induction of labour for improving outcomes

Non pharmacological interventions for spasticity in multiple sclerosis

Nurse versus physician-led care for the management of asthma

Optimal timing for antiretroviral therapy initiation in patients with HIV infection and concurrent cryptococcal meningitis

Oral H1 antihistamines as monotherapy for eczema

Progestogens or progestogen-releasing intrauterine systems for uterine fibroids

Red flags to screen for malignancy in patients with low-back pain

Restorative justice conferencing for reducing recidivism in young offenders (aged 7 to 21)

Spinal cord stimulation for cancer-related pain in adults

Surgical cytoreduction for recurrent epithelial ovarian cancer

The effect of pharmacist-provided non-dispensing services on patient outcomes, health service utilisation and costs in low- and middle-income countries

Training to recognise the early signs of recurrence in schizophrenia

Treatment of recurrent stress urinary incontinence after failed minimally invasive synthetic suburethral tape surgery in women



Update Reviews

Adjuvant radiotherapy and/or chemotherapy after surgery for uterine carcinosarcoma

Antibiotics for mastitis in breastfeeding women

Anti-D administration in pregnancy for preventing Rhesus alloimmunisation

Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients

Aripiprazole versus other atypical antipsychotics for schizophrenia

Baclofen for alcohol withdrawal

Chest physiotherapy for pneumonia in adults

Colloids versus crystalloids for fluid resuscitation in critically ill patients

Cyclophosphamide versus methylprednisolone for treating neuropsychiatric involvement in systemic lupus erythematosus

Drugs for treating Schistosoma mansoni infection

Effects of restricted caffeine intake by mother on fetal, neonatal and pregnancy outcome

Electromagnetic therapy for treating venous leg ulcers

Endothelin receptor antagonists for pulmonary arterial hypertension

Enzyme replacement therapy for Anderson-Fabry disease

Extramedullary fixation implants and external fixators for extracapsular hip fractures in adults

High-frequency ventilation versus conventional ventilation for treatment of acute lung injury and acute respiratory distress syndrome

Honey as a topical treatment for wounds

Intermittent versus daily inhaled corticosteroids for persistent asthma in children and adults

Interventions for smoking cessation and reduction in individuals with schizophrenia

Interventions for squamous cell carcinoma of the conjunctiva in HIV-infected individuals 

Intensity of exercise for the treatment of osteoarthritis (Withdrawn)

Laparoscopic repair for perforated peptic ulcer disease

Laparoscopy versus laparotomy for FIGO stage I ovarian cancer

Lung protective ventilation strategy for the acute respiratory distress syndrome

Macrolides for diffuse panbronchiolitis

Methadone at tapered doses for the management of opioid withdrawal

Methotrexate for ankylosing spondylitis

Multinutrient fortification of human breast milk for preterm infants following hospital discharge

Naloxone for opiate-exposed newborn infants

Nasal versus oral route for placing feeding tubes in preterm or low birth weight infants

Neuroprotection for treatment of glaucoma in adults

Nutritional interventions for reducing morbidity and mortality in people with HIV

Partial liquid ventilation for the prevention of mortality and morbidity in paediatric acute lung injury and acute respiratory distress syndrome

Perianal injectable bulking agents as treatment for faecal incontinence in adults

Personalised risk communication for informed decision making about taking screening tests

Pessaries (mechanical devices) for pelvic organ prolapse in women

Pharmacological treatment other than corticosteroids, intravenous immunoglobulin and plasma exchange for Guillain-Barré syndrome

Physical rehabilitation for older people in long-term care

Pre-emptive treatment for cytomegalovirus viraemia to prevent cytomegalovirus disease in solid organ transplant recipients

Prenatal education for congenital toxoplasmosis

Preoperative chemoradiation versus radiation alone for stage II and III resectable rectal cancer

Prophylactic gastrojejunostomy for unresectable periampullary carcinoma

Psychosocial and psychological interventions for preventing postpartum depression

Pulmonary artery catheters for adult patients in intensive care

School-based physical activity programs for promoting physical activity and fitness in children and adolescents aged 6 to 18

Spinal cord stimulation for non-reconstructable chronic critical leg ischaemia

Surgery for Ménière's disease

Surgery for scoliosis in Duchenne muscular dystrophy 

Therapeutic ultrasound for treating patellofemoral pain syndrome (Withdrawn)

Topical capsaicin (high concentration) for chronic neuropathic pain in adults

Transpyloric versus gastric tube feeding for preterm infants

Treatment of Lennox-Gastaut syndrome

Vaccines for preventing influenza in people with asthma


ARCHIVES 2012 2013

ISSUE 1 January 2013



Danielle Cohen & Elizabeth Corbett

Cochrane Database Syst Rev. 2013 Jan 31;1:ED000051.


Harriet Maclehose & John Hilton

Cochrane Database Syst Rev. 2013 Jan 31;1:ED000050.


New Reviews

Acupuncture for hypoxic ischemic encephalopathy in neonates

Antenatal interventions for reducing weight in obese women for improving pregnancy outcome

Anti-vascular endothelial growth factor for macular oedema secondary to branch retinal vein occlusion

Behavioral interventions for improving contraceptive use among women living with HIV

Cerebrolysin for vascular dementia

Exercise for improving outcomes after osteoporotic vertebral fracture

Gases for establishing pneumoperitoneum during laparoscopic abdominal surgery

High-volume haemofiltration for sepsis

Human chorionic gonadotrophin (hCG) for preventing miscarriage

Hysteroscopy for treating subfertility associated with suspected major uterine cavity abnormalities

Interventions for nail psoriasis

Interventions for treating persistent and intractable hiccups in adults

Intramuscular versus intravenous anti-D for preventing Rhesus alloimmunization during pregnancy

Multidisciplinary rehabilitation after primary brain tumour treatment

Neuromuscular electrical stimulation for muscle weakness in adults with advanced disease

Pharmacological therapies for maintenance treatments of opium dependence

Pharmacotherapy for hyperuricemia in hypertensive patients

Position in the second stage of labour for women with epidural anaesthesia

Red flags to screen for vertebral fracture in patients presenting with low-back pain

Selenium supplementation for the primary prevention of cardiovascular disease

Serotonin and noradrenaline reuptake inhibitors (SNRIs) for fibromyalgia syndrome

Slum upgrading strategies involving physical environment and infrastructure interventions and their effects on health and socio-economic outcomes

Surgical interventions for treating distal humeral fractures in adults

Surgical versus conservative interventions for displaced intra-articular calcaneal fractures

Telephone communication of HIV testing results for improving knowledge of HIV infection status

Thyroid hormones for acute kidney injury

Topical treatment for facial burns

Tranexamic acid for reducing mortality in emergency and urgent surgery

Treating BCG induced disease in children

Xpert ® MTB/RIF assay for pulmonary tuberculosis and rifampicin resistance in adults


Update Reviews

Antibiotics for acute otitis media in children

Antibiotics for treating acute chest syndrome in people with sickle cell disease

Antibiotics for treating bacterial vaginosis in pregnancy

Cervical assessment by ultrasound for preventing preterm delivery

Combination chemotherapy for primary treatment of high-risk gestational trophoblastic tumour

Cooling for newborns with hypoxic ischaemic encephalopathy

Depot versus daily administration of gonadotrophin-releasing hormone agonist protocols for pituitary down regulation in assisted reproduction cycles

Discharge planning from hospital to home

Educational games for health professionals

Enteral feeding methods for nutritional management in patients with head and neck cancers being treated with radiotherapy and/or chemotherapy

Ginkgo biloba extract for age-related macular degeneration

Homocysteine-lowering interventions for preventing cardiovascular events

Instruments for chorionic villus sampling for prenatal diagnosis

Interferon for interferon nonresponding and relapsing patients with chronic hepatitis C

Interventions for HIV-associated nephropathy

Interventions for preventing post-operative atrial fibrillation in patients undergoing heart surgery

Intrapartum antibiotics for known maternal Group B streptococcal colonization

Intravenous immunoglobulin as adjuvant therapy for Wegener's granulomatosis

Intravitreal low molecular weight heparin and 5-Fluorouracil for the prevention of proliferative vitreoretinopathy following retinal reattachment surgery

Laparoscopic surgery for presumed benign ovarian tumor during pregnancy

Laser-assisted in-situ keratomileusis (LASIK) versus photorefractive keratectomy (PRK) for myopia

Levonorgestrel-releasing intrauterine device (LNG-IUD) for symptomatic endometriosis following surgery

Non-steroidal anti-inflammatory drugs for heavy menstrual bleeding

Pain relief for women undergoing oocyte retrieval for assisted reproduction

Paracetamol/acetaminophen (single administration) for perineal pain in the early postpartum period

Phenobarbitone versus phenytoin monotherapy for partial onset seizures and generalised onset tonic-clonic seizures

Phytomedicines (medicines derived from plants) for sickle cell disease

Pressure-relieving interventions for treating diabetic foot ulcers

Primary surgery versus primary radiotherapy with or without chemotherapy for early adenocarcinoma of the uterine cervix

Screening for prostate cancer

Skin grafting for venous leg ulcers

Skin preparation with alcohol versus alcohol followed by any antiseptic for preventing bacteraemia or contamination of blood for transfusion

Statins for the primary prevention of cardiovascular disease

Sucrose for analgesia in newborn infants undergoing painful procedures

Surgical implantation of steroids with antiangiogenic characteristics for treating neovascular age-related macular degeneration

Use of plastic adhesive drapes during surgery for preventing surgical site infection

Vaccines for preventing pneumococcal infection in adults

Vaginal preparation with antiseptic solution before cesarean section for preventing postoperative infections

Vibroacoustic stimulation for fetal assessment in labour in the presence of a nonreassuring fetal heart rate trace

Vigabatrin for refractory partial epilepsy

Vitamin C for preventing and treating the common cold


ARCHIVES 2012 2013 2014 back to current

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