2014 Table of contents Archives


ISSUE 12 December 2014 (completed)



 The emerging epidemic of endometrial cancer: time to take action

 Emma Crosbie & Jo Morrison

 Cochrane Database Syst Rev. 2014 December 22;12:ED000095



 Erythropoiesis-stimulating agents for anaemia in chronic kidney disease: are they all the same?

 David Mudge & Angela Webster

 Cochrane Database Syst Rev. 2014 December 9;12:ED000093


New Reviews

Adjuvant chemotherapy after concurrent chemoradiation for locally advanced cervical cancer 

Antibiotic regimens for management of intra-amniotic infection 

Antidepressants for people with epilepsy and depression 

Biologics, colchicine, corticosteroids, immunosuppressants and interferon-alpha for Neuro-Behçet's Syndrome 

Cardiac rehabilitation for people with heart disease: an overview of Cochrane systematic reviews 

Co-enzyme Q10 supplementation for the primary prevention of cardiovascular disease 

Conservative versus interventional management for primary spontaneous pneumothorax in adults 

Cordyceps sinensis (a traditional Chinese medicine) for treating chronic kidney disease 

Creatine for women in pregnancy for neuroprotection of the fetus 

Diaries for recovery from critical illness 

Electronic cigarettes for smoking cessation and reduction 

Ephedrine for myasthenia gravis, neonatal myasthenia and the congenital myasthenic syndromes

Erythropoiesis-stimulating agents for anaemia in adults with chronic kidney disease: a network meta-analysis 

HIV prevention advice for people with serious mental illness 

Immunonutrition as an adjuvant therapy for burns 

Intraoperative local anaesthesia for reduction of postoperative pain following general anaesthesia for dental treatment in children and adolescents 

Intermittent self-dilatation for urethral stricture disease in males 

Interventions for fatigue in peripheral neuropathy 

Interventions for melanoma in situ, including lentigo maligna 

Interventions for preventing and ameliorating cognitive deficits in adults treated with cranial irradiation 

Interventions for treating painful nipples among breastfeeding women 

Iron therapy in anaemic adults without chronic kidney disease

Isotonic versus hypotonic solutions for maintenance intravenous fluid administration in children

Long-term proton pump inhibitor (PPI) use and the development of gastric pre-malignant lesions 

Ovarian cyst aspiration prior to in vitro fertilization treatment for subfertility

Peripheral nerve blocks for postoperative pain after major knee surgery 

Pharmacotherapies for cannabis dependence

Prophylactic manual rotation for fetal malposition to reduce operative delivery 

Rapid diagnostic tests for diagnosing uncomplicated non-falciparum or Plasmodium vivax malaria in endemic countries 

Robot-assisted surgery in gynaecology 

Stereotactic radiotherapy for vestibular schwannoma 

Surgical versus medical interventions for chronic rhinosinusitis with nasal polyps 

Timing of intravenous prophylactic antibiotics for preventing postpartum infectious morbidity in women undergoing cesarean delivery 

Transcendental meditation for the primary prevention of cardiovascular disease

Treatment for cryoglobulinemic and non-cryoglobulinemic peripheral neuropathy associated with hepatitis C virus infection 

Vitamin E supplementation in people with cystic fibrosis 


Updated Review

Antibiotic treatment for nontuberculous mycobacteria lung infection in people with cystic fibrosis

Antioxidants for male subfertility 

Assisted reproductive technology: an overview of Cochrane Reviews 

Balloon angioplasty, with and without stenting, versus medical therapy for hypertensive patients with renal artery stenosis 

Bladder neck needle suspension for urinary incontinence in women 

Calcimimetics for secondary hyperparathyroidism in chronic kidney disease patients 

Compulsory community and involuntary outpatient treatment for people with severe mental disorders

Delayed introduction of progressive enteral feeds to prevent necrotising enterocolitis in very low birth weight infants 

Different durations of corticosteroid therapy for exacerbations of chronic obstructive pulmonary disease

Different types of intermittent pneumatic compression devices for preventing venous thromboembolism in patients after total hip replacement 

Disposable nappies for preventing napkin dermatitis in infants 

Early versus delayed oral fluids and food for reducing complications after major abdominal gynaecologic surgery

Elective repeat caesarean section versus induction of labour for women with a previous caesarean birth 

Endoscopic pneumatic dilation versus botulinum toxin injection in the management of primary achalasia 

Glutamine supplementation for young infants with severe gastrointestinal disease 

Graduated compression stockings for prevention of deep vein thrombosis 

Herbal medicine for low-back pain 

Honey for acute cough in children 

Household interventions for preventing domestic lead exposure in children 

Immediate-release versus controlled-release carbamazepine in the treatment of epilepsy 

Interventions for treating leg ulcers in people with sickle cell disease 

Interventions to improve return to work in depressed people

Local intramuscular transplantation of autologous mononuclear cells for critical lower limb ischaemia

Mechanical devices for urinary incontinence in women 

Mohs micrographic surgery versus surgical excision for periocular basal cell carcinoma

Music interventions for mechanically ventilated patients 

Negative pressure wound therapy for partial-thickness burns

Nocturnal mechanical ventilation for chronic hypoventilation in patients with neuromuscular and chest wall disorders 

Osteotomy for treating knee osteoarthritis 

Oxygen therapy for lower respiratory tract infections in children between 3 months and 15 years of age 

Parenteral anticoagulation in ambulatory patients with cancer 

Patient education for preventing diabetic foot ulceration 

Preventing occupational stress in healthcare workers 

Psychosocial interventions to reduce alcohol consumption in concurrent problem alcohol and illicit drug users 

Radiotherapy versus open surgery versus endolaryngeal surgery (with or without laser) for early laryngeal squamous cell cancer 

Reduced dietary salt for the prevention of cardiovascular disease

Restricted versus liberal water intake for preventing morbidity and mortality in preterm infants

Slow advancement of enteral feed volumes to prevent necrotising enterocolitis in very low birth weight infants 

Statins for primary prevention of venous thromboembolism

Surfactant for meconium aspiration syndrome in term and late preterm infants 

Synchronised approach for intrauterine insemination in subfertile couples 

The Epley (canalith repositioning) manoeuvre for benign paroxysmal positional vertigo 

Universal school-based prevention for illicit drug use  

Ursodeoxycholic acid for cystic fibrosis-related liver disease 

Use of electronic health records to support smoking cessation 

Uterine artery embolization for symptomatic uterine fibroids 

Vaginal chlorhexidine during labour to prevent early-onset neonatal group B streptococcal infection 

Vaginal preparation with antiseptic solution before cesarean section for preventing postoperative infections 


Withdrawn Reviews

Robotic assisted surgery for gynaecological cancer

Robotic surgery for benign gynaecological disease


ISSUE 11 November 2014 (Completed)



 How should we describe worsening asthma in Cochrane reviews, and does it matter?

 Rebecca Normansell, on behalf of the Cochrane Airways Group editorial board

 Cochrane Database Syst Rev. 2014 November 12;11:ED000092


New Reviews

Adjunctive steroid therapy for managing pulmonary tuberculosis 

Aerobic physical exercise for adult patients with haematological malignancies 

Anaesthetic techniques for risk of malignant tumour recurrence 

Anti-vascular endothelial growth factor for proliferative diabetic retinopathy

Artificial corneas versus donor corneas for repeat corneal transplants 

Aspiration and sclerotherapy versus hydrocoelectomy for treating hydrocoeles

Aspiration of the elbow joint for treating radial head fractures 

Belatacept for kidney transplant recipients 

Biomarkers as point-of-care tests to guide prescription of antibiotics in patients with acute respiratory infections in primary care 

Blood pressure lowering efficacy of partial agonist beta blocker monotherapy for primary hypertension 

Chemotherapy with cetuximab versus chemotherapy alone for chemotherapy-naive advanced non-small cell lung cancer 

Exercise for cancer cachexia in adults 

Exercise for reducing fear of falling in older people living in the community 

Gene therapy for haemophilia 

H1-antihistamines for chronic spontaneous urticaria 

Home versus in-centre haemodialysis for end-stage kidney disease 

Imiquimod for anogenital warts in non-immunocompromised adults 

Interventions aimed at communities to inform and/or educate about early childhood vaccination

Interventions for improving upper limb function after stroke 

Interventions for the management of taste disturbances

Interventions for treating inadvertent postoperative hypothermia 

Interventions for women in subsequent pregnancies following obstetric anal sphincter injury to reduce the risk of recurrent injury and associated harms 

Laser photocoagulation for proliferative diabetic retinopathy 

Lipid-lowering efficacy of rosuvastatin 

Non-pharmacological interventions for chronic pain in people with spinal cord injury

Non-pharmacological interventions for preventing job loss in workers with inflammatory arthritis 

Non-pharmacological interventions for somatoform disorders and medically unexplained physical symptoms (MUPS) in adults

Non-surgical interventions for treating heavy menstrual bleeding (menorrhagia) in women with bleeding disorders

Oral and sublingual immunotherapy for egg allergy

Outpatient versus inpatient treatment for acute pulmonary embolism 

Pentoxifylline for the prevention of bronchopulmonary dysplasia in preterm infants 

PET-CT for assessing mediastinal lymph node involvement in patients with suspected resectable non-small cell lung cancer 

Pharmacological interventions for somatoform disorders in adults

Pharmacological treatment of children with gastro-oesophageal reflux 

Psychological, social and welfare interventions for psychological health and well-being of torture survivors 

Restricting or banning alcohol advertising to reduce alcohol consumption in adults and adolescents

Strategies for improving postpartum contraceptive use: evidence from non-randomized studies 

Surgical interventions for chronic rhinosinusitis with nasal polyps 

Surgical interventions for treating fractures of the olecranon in adults 

Uricosuric medications for chronic gout 

Wound drainage following groin dissection for malignant disease in adults 


Updated Reviews

Amantadine and rimantadine for influenza A in children and the elderly 

Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis 

Antibiotics for meconium-stained amniotic fluid in labour for preventing maternal and neonatal infections 

Antifungal therapies for allergic bronchopulmonary aspergillosis in people with cystic fibrosis 

Deep transverse friction massage for treating lateral elbow or lateral knee tendinitis 

Different classes of antibiotics given to women routinely for preventing infection at caesarean section

Droperidol for treatment of nausea and vomiting in palliative care patients 

Early additional food and fluids for healthy breastfed full-term infants

Exercise for vasomotor menopausal symptoms 

Extracorporeal shock wave lithotripsy (ESWL) versus percutaneous nephrolithotomy (PCNL) or retrograde intrarenal surgery (RIRS) for kidney stones

Garlic for the common cold 

Hepatitis B vaccination during pregnancy for preventing infant infection

Hyperbaric oxygen therapy for acute ischaemic stroke 

Interventions for enhancing medication adherence 

Interventions for preventing or reducing domestic violence against pregnant women 

Manual small incision cataract surgery (MSICS) with posterior chamber intraocular lens versus extracapsular cataract extraction (ECCE) with posterior chamber intraocular lens for age-related cataract 

Metformin treatment before and during IVF or ICSI in women with polycystic ovary syndrome

Oral calorie supplements for cystic fibrosis 

Over-the-counter (OTC) medications for acute cough in children and adults in community settings

Pharmacological and nutritional treatment for McArdle disease (Glycogen Storage Disease type V) 

Preventing occupational stress in healthcare workers 

Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease 

Prophylactic anti-staphylococcal antibiotics for cystic fibrosis 

Protocolized versus non-protocolized weaning for reducing the duration of mechanical ventilation in critically ill adult patients 

Psychological therapies versus antidepressant medication, alone and in combination for depression in children and adolescents 

Pylorus-preserving pancreaticoduodenectomy (pp Whipple) versus pancreaticoduodenectomy (classic Whipple) for surgical treatment of periampullary and pancreatic carcinoma

Reminder systems to improve patient adherence to tuberculosis clinic appointments for diagnosis and treatment 

Routine perineal shaving on admission in labour 

Salicylate-containing rubefacients for acute and chronic musculoskeletal pain in adults 

Slow-release fluoride devices for the control of dental decay 

Strategies for expanding health insurance coverage in vulnerable populations

Sulfasalazine for ankylosing spondylitis 

Tissue adhesives for closure of surgical incisions

Tonsillectomy or adenotonsillectomy versus non-surgical treatment for chronic/recurrent acute tonsillitis 

Tranexamic acid for upper gastrointestinal bleeding 

Treatment for thoracic outlet syndrome 



Acupuncture-point stimulation for chemotherapy-induced nausea or vomiting  


ISSUE 10 OCtober 2014 (completed)


New Reviews

Acupuncture for functional dyspepsia

Advanced sperm selection techniques for assisted reproduction 

Allopurinol for chronic gout 

Ambroxol for women at risk of preterm birth for preventing neonatal respiratory distress syndrome

Anabolic steroids for rehabilitation after hip fracture in older people 

Androgens for the anaemia of chronic kidney disease in adults

Antibiotics prior to amniotomy for reducing infectious morbidity in mother and infant 

Antiepileptic drugs for the primary and secondary prevention of seizures in viral encephalitis 

Antiretroviral interventions for preventing breast milk transmission of HIV 

Aquatic exercise training for fibromyalgia 

Astragalus (a traditional Chinese medicine) for treating chronic kidney disease

Bias due to selective inclusion and reporting of outcomes and analyses in systematic reviews of randomised trials of healthcare interventions 

Capsule endoscopy for the diagnosis of oesophageal varices in people with chronic liver disease or portal vein thrombosis

Clobazam monotherapy for partial-onset or generalized-onset seizures 

Dietary supplements for chronic gout 

Early versus late initiation of epidural analgesia for labour 

Eculizumab for treating patients with paroxysmal nocturnal hemoglobinuria 

Electrotherapy modalities for adhesive capsulitis (frozen shoulder) 

Eradication therapy for Burkholderia cepacia complex in people with cystic fibrosis 

Fetal assessment methods for improving neonatal and maternal outcomes in preterm prelabour rupture of membranes 

Heparin versus 0.9% sodium chloride intermittent flushing for prevention of occlusion in central venous catheters in adults

Hepatitis B vaccination for reducing morbidity and mortality in persons with HIV infection 

High-dose versus low-dose oxytocin infusion regimens for induction of labour at term 

Interventions for managing asthma in pregnancy 

Interventions for primary prevention of suicide in university and other post-secondary educational settings 

Interventions for tophi in gout 

Intranasal fentanyl for the management of acute pain in children

Minimally invasive surgical techniques versus open myomectomy for uterine fibroids 

Non-nutritive sucking for gastro-oesophageal reflux disease in preterm and low birth weight infants

Non-pharmaceutical management of respiratory morbidity in children with severe global developmental delay

Oral adsorbents for preventing or delaying the progression of chronic kidney disease

Pancreatic enzyme replacement therapy for people with cystic fibrosis 

Perphenazine versus low-potency first-generation antipsychotic drugs for schizophrenia

Pharmacotherapy for sleep bruxism

Prenatal versus postnatal repair procedures for spina bifida for improving infant and maternal outcomes 

Probiotics for preventing ventilator-associated pneumonia 

School policies for preventing smoking among young people 

Strabismus surgery before versus after completion of amblyopia therapy in children 

Strategies of testing for syphilis during pregnancy

Surgical approaches for cervical spine facet dislocations in adults 

Surgical interventions for treating pectus excavatum 

The diagnostic accuracy of the GenoType® MTBDRsl assay for the detection of resistance to second-line anti-tuberculosis drugs

Tolerability of selective cyclooxygenase 2 inhibitors used for the treatment of rheumatological manifestations of inflammatory bowel disease 

Treatment for epilepsy in pregnancy: neurodevelopmental outcomes in the child 

Treatment for speech disorder in Friedreich ataxia and other hereditary ataxia syndromes 

Vasodilators for women undergoing fertility treatment 

Virtual reality for treatment compliance for people with serious mental illness 


Updated Review

Acetylcholinesterase inhibitor treatment for myasthenia gravis 

Acupuncture for schizophrenia 

Antibiotic prophylaxis for operative vaginal delivery 

Antibiotic prophylaxis for third- and fourth-degree perineal tear during vaginal birth 

Antibiotic prophylaxis versus no prophylaxis for preventing infection after cesarean section 

Antibiotics for bronchiolitis in children under two years of age 

Antibiotics for community-acquired pneumonia in adult outpatients 

Antibiotics for prelabour rupture of membranes at or near term 

Anticoagulation for people with cancer and central venous catheters

Anti-vascular endothelial growth factor for diabetic macular oedema 

Beta-blockers for preventing stroke recurrence

Cannabis and schizophrenia 

Cilostazol for intermittent claudication 

Colony-stimulating factors for chemotherapy-induced febrile neutropenia 

Decongestants, antihistamines and nasal irrigation for acute sinusitis in children 

Deferasirox for managing iron overload in people with myelodysplastic syndrome 

Drugs for preventing malaria in pregnant women in endemic areas: any drug regimen versus placebo or no treatment 

Epinephrine injection versus epinephrine injection and a second endoscopic method in high-risk bleeding ulcers 

Fetal pulse oximetry for fetal assessment in labour

Gene therapy for sickle cell disease 

Gonadotropin-releasing hormone agonist versus HCG for oocyte triggering in antagonist-assisted reproductive technology 

Hematopoietic stem cell transplantation for people with ß-thalassaemia major 

High dose rate versus low dose rate intracavity brachytherapy for locally advanced uterine cervix cancer 

Immunosuppressive treatment for idiopathic membranous nephropathy in adults with nephrotic syndrome

Immunotherapy for recurrent miscarriage

Inhaled corticosteroids for cystic fibrosis 

Interventions for deliberately altering blood pressure in acute stroke 

Interventions for dysphagia in oesophageal cancer 

Interventions to improve the appropriate use of polypharmacy for older people

Intravenous lidocaine for the treatment of background or procedural burn pain 

Negative pressure wound therapy for skin grafts and surgical wounds healing by primary intention 

Omentoplasty for oesophagogastrostomy after oesophagectomy 

Pharmaceutical policies: effects of reference pricing, other pricing, and purchasing policies 

Pulmonary rehabilitation for interstitial lung disease 

Prophylactic antibiotics for manual removal of retained placenta in vaginal birth

Prophylaxis for Pneumocystis pneumonia (PCP) in non-HIV immunocompromised patients 

Quantitative versus qualitative cultures of respiratory secretions for clinical outcomes in patients with ventilator-associated pneumonia

Topical corticosteroids as adjunctive therapy for bacterial keratitis 


Withdrawn Reviews



ISSUE 9 September 2014 (COMPLETE)



 #CochraneTech: technology and the future of systematic reviews

 Julian Elliott, Ida Sim, Jessica Thomas, Nancy Owens, Gordon Dooley, Jacob Riis, Byron Wallace, James Thomas, Anna Noel-Storr, Gabriel Rada, Caroline Struthers, Tracey Howe, Harriet MacLehose, Linn Brandt, Ilkka Kunnamo & Chris Mavergames

 Cochrane Database Syst Rev. 2014 September 19;9:ED000091



 A clearer view of evidence in treating macular degeneration: off-label policies and  independent research

 Giulio Formoso, Anna Maria Marata, Nicola Magrini & Lisa Bero

 Cochrane Database Syst Rev. 2014 September 15;9:ED000090



 When trial authors write Cochrane Reviews: competing interests need to be better  managed

 Merav Kliner & Paul Garner

 Cochrane Database Syst Rev. 2014 September 10;9:ED000089



 Large evidence base, small effects: motivational interviewing for alcohol misuse in  young adults

 Marina Davoli & Laura Amato

 Cochrane Database Syst Rev. 2014 September 3;9:ED000088


New Reviews

Aclidinium bromide for stable chronic obstructive pulmonary disease

Antiangiogenic therapy for high-grade glioma

Artemether for severe malaria 

Automated weaning and SBT systems versus non-automated weaning strategies for weaning time in invasively ventilated critically ill adults 

Azapirones versus placebo for panic disorder in adults 

Cardiopulmonary resuscitation (CPR) plus delayed defibrillation versus immediate defibrillation for out-of-hospital cardiac arrest 

Centre-based day care for children younger than five years of age in high-income countries

Centre-based day care for children younger than five years of age in low- and middle-income countries

Certolizumab pegol (CDP870) for rheumatoid arthritis in adults

Cervical stitch (cerclage) for preventing preterm birth in multiple pregnancy 

Clinical pathways for chronic cough in children

Codeine, alone and with paracetamol (acetaminophen), for cancer pain

Comparison of antiepileptic drugs, no treatment, or placebo for children with benign epilepsy with centro temporal spikes 

Computed tomography angiography or magnetic resonance angiography for detection of intracranial vascular malformations in patients with intracerebral haemorrhage

Desipramine for neuropathic pain in adults

Down-titration and discontinuation strategies of tumor necrosis factor–blocking agents for rheumatoid arthritis in patients with low disease activity

Effects of sevoflurane versus other general anaesthesia on emergence agitation in children 

Efficacy and experiences of telephone counselling for informal carers of people with dementia

Flupenthixol versus low-potency first-generation antipsychotic drugs for schizophrenia  

Glutamine supplementation for critically ill adults 

Haemophilus influenzae oral vaccination for preventing acute exacerbations of chronic bronchitis and chronic obstructive pulmonary disease 

Immediate-release methylphenidate for attention deficit hyperactivity disorder (ADHD) in adults

Interleukin-1 inhibitors for acute gout

Interventions for the management of oral ulcers in Behçet's disease

Interventions for treating postpartum constipation

Interventions for treating simple bone cysts in the long bones of children 

Intracystic bleomycin for cystic craniopharyngiomas in children

Intravenous immunoglobulin for Guillain-Barré syndrome

Minimally invasive discectomy versus microdiscectomy/open discectomy for symptomatic lumbar disc herniation 

Non-steroidal anti-inflammatory drugs for acute gout 

Orthodontic and orthopaedic treatment for anterior open bite in children

Perioperative beta-blockers for preventing surgery-related mortality and morbidity

Pre-hospital versus in-hospital thrombolysis for ST-elevation myocardial infarction 

Repeated use of pre- and postcoital hormonal contraception for prevention of pregnancy

Repetitive transcranial magnetic stimulation (rTMS) for panic disorder in adults

Steroid avoidance or withdrawal for pancreas and pancreas with kidney transplant recipients 

Surgery for stress urinary incontinence due to presumed sphincter deficiency after prostate surgery

Surgery for treating hip impingement (femoroacetabular impingement) 

Symptomatic treatment of the cough in whooping cough

Systemic safety of bevacizumab versus ranibizumab for neovascular age-related macular degeneration 

Techniques to ascertain correct endotracheal tube placement in neonates 

Topical corticosteroids for treating phimosis in boys 

Tricyclic antidepressants for attention deficit hyperactivity disorder (ADHD) in children and adolescents

Types of indwelling urethral catheters for short-term catheterisation in hospitalised adults

Vitrification versus slow freezing for women undergoing oocyte cryopreservation 


Updated Reviews

Acellular vaccines for preventing whooping cough in children 

Amphotericin B lipid soluble formulations versus amphotericin B in cancer patients with neutropenia

Amphotericin B versus fluconazole for controlling fungal infections in neutropenic cancer patients

Anticonvulsant therapy for status epilepticus 

Antidepressant treatment for postnatal depression 

Antigen-specific active immunotherapy for ovarian cancer

Compression for preventing recurrence of venous ulcers 

Computer-assisted surgery for knee ligament reconstruction 

Culturally appropriate health education for people in ethnic minority groups with type 2 diabetes mellitus 

Dressings for the prevention of surgical site infection

Evaluation of follow-up strategies for patients with epithelial ovarian cancer following completion of primary treatment 

Intermittent catheterisation for long-term bladder management 

Interventions for asymptomatic retinal breaks and lattice degeneration for preventing retinal detachment 

Interventions for improving the adoption of shared decision making by healthcare professionals

Intramedullary nails for extracapsular hip fractures in adults 

Multidisciplinary biopsychosocial rehabilitation for chronic low back pain 

Nasal intermittent positive pressure ventilation (NIPPV) versus nasal continuous positive airway pressure (NCPAP) for preterm neonates after extubation 

Nystatin prophylaxis and treatment in severely immunodepressed patients 

Oral or transdermal opioids for osteoarthritis of the knee or hip 

Oral zinc for arterial and venous leg ulcers 

Rapid viral diagnosis for acute febrile respiratory illness in children in the Emergency Department 

Recombinant human growth hormone for treating burns and donor sites 

Routine versus selective antifungal administration for control of fungal infections in patients with cancer 

Self-management education for cystic fibrosis 

Skin preparation for preventing infection following caesarean section 

Statins for acute coronary syndrome 

Systemic corticosteroids for acute exacerbations of chronic obstructive pulmonary disease

Tonsillectomy for periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome (PFAPA) 

Treatment including anthracyclines versus treatment not including anthracyclines for childhood cancer

Treatment of severe or progressive Kaposi's sarcoma in HIV-infected adults

Vaginal chlorhexidine during labour for preventing maternal and neonatal infections (excluding Group B Streptococcal and HIV) 

Vaginal dilator therapy for women receiving pelvic radiotherapy 

Vaginal preparation with antiseptic solution before cesarean section for preventing postoperative infections 








New Reviews

Angiotensin converting enzyme (ACE) inhibitors versus angiotensin receptor blockers for primary hypertension

Antioxidants for pain in chronic pancreatitis

Aspirin as adjunctive treatment for giant cell arteritis 

Azathioprine and 6-mercaptopurine for maintenance of surgically-induced remission in Crohn's disease  

Colchicine for pericarditis

Continuous positive airway pressure (CPAP) during the postoperative period for prevention of postoperative morbidity and mortality following major abdominal surgery 

Dental auxiliaries for dental care traditionally provided by dentists

Exercise for people with high cardiovascular risk 

Endovascular versus open repair of asymptomatic popliteal artery aneurysm 

Fluphenazine versus low-potency first-generation antipsychotic drugs for schizophrenia 

Hypnosis for induction of labour 

Interventions for treating acute bleeding episodes in people with acquired hemophilia A

Manual therapy and exercise for adhesive capsulitis (frozen shoulder)

Motivational interviewing for alcohol misuse in young adults

Oral antiviral therapy for prevention of genital herpes outbreaks in immunocompetent and nonpregnant patients 

Periodontal therapy for the management of cardiovascular disease in patients with chronic periodontitis 

Preoperative carbohydrate treatment for enhancing recovery after elective surgery 

Pharmacological interventions for sleepiness and sleep disturbances caused by shift work

Spectacle correction versus no spectacles for prevention of strabismus in hyperopic children

Surgical intervention versus expectant management for endometrial polyps in subfertile women

Time course for blood pressure lowering of dihydropyridine calcium channel blockers

Topical antifungal treatments for tinea cruris and tinea corporis 


Updated Reviews

Advanced training in trauma life support for ambulance crews

Advanced trauma life support training for hospital staff

Antiepileptic drugs for the primary and secondary prevention of seizures after intracranial venous thrombosis

Antioxidant supplementation for lung disease in cystic fibrosis

Anti-vascular endothelial growth factor for neovascular age-related macular degeneration 

Budesonide for maintenance of remission in Crohn's disease

Closure versus non-closure of the peritoneum at caesarean section: short- and long-term outcomes  

Colchicine for acute gout 

Computer-assisted surgery for knee ligament reconstruction 

Double bag or Y-set versus standard transfer systems for continuous ambulatory peritoneal dialysis in end-stage kidney disease

Duration of treatment with vitamin K antagonists in symptomatic venous thromboembolism 

Drugs for treating urinary schistosomiasis 

Exercise interventions for smoking cessation

Exit interviews to reduce turnover amongst healthcare professionals

Gamma aminobutyric acid (GABA) receptor agonists for acute stroke 

Glucocorticoid with cyclophosphamide for paraquat-induced lung fibrosis 

Haemodilution for acute ischaemic stroke

Inhaled bronchodilators for acute chest syndrome in people with sickle cell disease 

Interventions for congenital talipes equinovarus (clubfoot) 

Interventions to reduce haemorrhage during myomectomy for fibroids 

Magnesium sulphate for preventing preterm birth in threatened preterm labour

Methotrexate for induction of remission in refractory Crohn's disease 

Methotrexate for induction of remission in ulcerative colitis

Methotrexate for maintenance of remission in Crohn's disease

Modest cooling therapies (35°C to 37.5°C) for traumatic brain injury

Monitoring of stimulated cycles in assisted reproduction (IVF and ICSI)

Orthodontic treatment for posterior crossbites 

Pneumococcal vaccines for cystic fibrosis 

Post-embryo transfer interventions for assisted reproduction technology cycles

Primary prophylaxis for venous thromboembolism in ambulatory cancer patients receiving chemotherapy 

Pulp treatment for extensive decay in primary teeth 

Reinforcement of anchorage during orthodontic brace treatment with implants or other surgical methods

Removal of nail polish and finger rings to prevent surgical infection 

Surgery for weight loss in adults 

Treatment of severe or progressive Kaposi's sarcoma in HIV-infected adults 

Urate oxidase for the prevention and treatment of tumour lysis syndrome in children with cancer 

Vedolizumab for induction and maintenance of remission in ulcerative colitis 


Withdrawn Reviews

Laparoscopic surgery for pelvic pain associated with endometriosis 

Laparoscopic surgery for subfertility associated with endometriosis 

Non-invasive physical treatments for chronic/recurrent headache 

Treatment for swallowing difficulties (dysphagia) in chronic muscle disease 





 Cochrane Clinical Answers: putting Cochrane Reviews in clinical context

 Sera Tort, Karen Pettersen & David Tovey

 Cochrane Database Syst Rev. 2014 July 25;7:ED000087



 When will research measure up to our need to know how steroids affect childhood growth?

 James Paton

 Cochrane Database Syst Rev. 2014 July 17;7:ED000086




New Reviews

11C-PIB-PET for the early diagnosis of Alzheimer's disease dementia and other dementias in people with mild cognitive impairment (MCI)

Air versus saline in the loss of resistance technique for identification of the epidural space

Alternating current cranial electrotherapy stimulation (CES) for depression

Antenatal breast milk expression by women with diabetes for improving infant outcomes

Antimetabolites in cataract surgery to prevent failure of a previous trabeculectomy

Appetite stimulants for people with cystic fibrosis

Baby-led compared with scheduled (or mixed) breastfeeding for successful breastfeeding

Chinese herbal medicines for treating skin and soft-tissue infections

Combination of tocolytic agents for inhibiting preterm labour

Continuous versus bolus intragastric tube feeding for preterm and low birth weight infants with gastro-oesophageal reflux disease

Daily sedation interruption versus no daily sedation interruption for critically ill adult patients requiring invasive mechanical ventilation

Deep anterior lamellar keratoplasty versus penetrating keratoplasty for treating keratoconus

Haloperidol versus low-potency first-generation antipsychotic drugs for schizophrenia

Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) for the diagnosis of dementia within a general practice (primary care) setting

Inhaled anticholinergics and short-acting beta2-agonists versus short-acting beta2-agonists alone for children with acute asthma in hospital

Inhaled corticosteroids in children with persistent asthma: dose-response effects on growth

Inhaled corticosteroids in children with persistent asthma: effects on growth

Interferons-beta versus glatiramer acetate for relapsing-remitting multiple sclerosis

Interventions for treating femoral shaft fractures in children and adolescents

Interventions to improve hearing aid use in adult auditory rehabilitation

Levetiracetam for neuropathic pain in adults

Topical lidocaine for neuropathic pain in adults

Mannitol versus hypertonic saline for brain relaxation in patients undergoing craniotomy

Methods for securing endotracheal tubes in newborn infants

Modes of exercise training for intermittent claudication

Mycophenolate mofetil versus methotrexate for prevention of graft-versus-host disease in people receiving allogeneic hematopoietic stem cell transplantation

Nalbuphine for postoperative pain treatment in children

Oral or parenteral iron supplementation to reduce deferral, iron deficiency and/or anaemia in blood donors

Pharmacological interventions for preventing post-traumatic stress disorder (PTSD)

Phototherapy for treating pressure ulcers

Physician anaesthetists versus non-physician providers of anaesthesia for surgical patients

Relaxation for perimenopausal and postmenopausal symptoms

Slow versus fast subcutaneous heparin injections for prevention of bruising and site-pain intensity

Structural and community-level interventions for increasing condom use to prevent the transmission of HIV and other sexually transmitted infections

Surgical techniques for the removal of mandibular wisdom teeth

Trifluoperazine versus low-potency first-generation antipsychotic drugs for schizophrenia

Water-based exercise for adults with asthma

Updated Reviews

Antibiotics for acute pyelonephritis in children

Anticoagulation for the long-term treatment of venous thromboembolism in patients with cancer

Aspirin and/or heparin for women with unexplained recurrent miscarriage with or without inherited thrombophilia

Bicarbonate versus lactate solutions for acute peritoneal dialysis

Bisphosphonate therapy for osteogenesis imperfecta

Botulinum toxin for myofascial pain syndromes in adults

Continuous or extended cycle vs. cyclic use of combined hormonal contraceptives for contraception

Continuous passive motion for preventing venous thromboembolism after total knee arthroplasty

Corticosteroids for dengue infection

Drug therapies for reducing gastric acidity in people with cystic fibrosis

Endovascular treatment for ruptured abdominal aortic aneurysm

Endovenous ablation (radiofrequency and laser) and foam sclerotherapy versus open surgery for great saphenous vein varices

Exercise for intermittent claudication

Felbamate as an add-on therapy for refractory epilepsy

Fluid and pharmacological agents for adhesion prevention after gynaecological surgery

Humanized PA14 (a monoclonal CCR5 antibody) for treatment of people with HIV infection

Hysterectomy versus hysterectomy plus oophorectomy for premenopausal women

Immediate postabortal insertion of intrauterine devices

Inhaled nitric oxide for the postoperative management of pulmonary hypertension in infants and children with congenital heart disease

Interventions for strabismic amblyopia

Interventions for replacing missing teeth: different types of dental implants

Interventions to increase influenza vaccination rates of those 60 years and older in the community

Medical interventions for the prevention of platinum-induced hearing loss in children with cancer

Oral anticoagulation in patients with cancer who have no therapeutic or prophylactic indication for anticoagulation

Oscillating devices for airway clearance in people with cystic fibrosis

Short-term psychodynamic psychotherapies for common mental disorders

Statins for children with familial hypercholesterolemia

Statins for the treatment of dementia

Surgical techniques for uterine incision and uterine closure at the time of caesarean section

Task shifting from doctors to non-doctors for initiation and maintenance of antiretroviral therapy

Therapeutic touch for healing acute wounds

Thrombolysis for acute ischaemic stroke

Tiotropium versus placebo for chronic obstructive pulmonary disease

Treatment for avascular necrosis of bone in people with sickle cell disease

Withdrawn Reviews

Dipyrone for acute primary headaches

Drugs for preventing migraine headaches in children

Laser therapy for venous leg ulcers

Pre-operative endometrial thinning agents before endometrial destruction for heavy menstrual bleeding

Transcutaneous electrical nerve stimulation (TENS) for chronic pain



 vitamin d for preventing cancer: evidence and health beliefs

 Bernd Richter

 Cochrane Database Syst Rev. 2014 June 24;6:ED000085



 Not too little, not too much: delivering the right amount of anaesthesia during surgery

 Stephen Kettner

 Cochrane Database Syst Rev. 2014 June 17;6:ED000084



 Treating metastatic breast cancer: the evidence for targeted therapy

 Nicholas Wilcken

 Cochrane Database Syst Rev. 2014 June 12;6:ED000083




New Reviews

Acupuncture for treating acute ankle sprains in adults 

Aloe vera for prevention and treatment of infusion phlebitis 

Aminoadamantanes versus other antiviral drugs for chronic hepatitis C 

Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers for preserving residual kidney function in peritoneal dialysis patients 

Antibody induction versus placebo, no induction, or another type of antibody induction for liver transplant recipients 

Anticoagulation therapy versus placebo for pulmonary hypertension

Antimicrobial drugs for treating cholera 

Coenzyme Q10 for heart failure

Combination inhaled corticosteroids and long-acting beta2-agonists for children and adults with bronchiectasis

Continuous renal replacement therapy (CRRT) for rhabdomyolysis 

Creatine for Parkinson's disease 

Deep brain and cortical stimulation for epilepsy 

Different infusion durations for preventing platinum-induced hearing loss in children with cancer

Early referral to specialist nephrology services for preventing the progression to end-stage kidney disease 

Effectiveness of different nursing handover styles for ensuring continuity of information in hospitalised patients

Extra fluids for breastfeeding mothers for increasing milk production 

Home- versus hospital-based phototherapy for the treatment of non-haemolytic jaundice in infants at more than 37 weeks' gestation 

Information and communication technology based prompting for treatment compliance for people with serious mental illness 

Levothyroxine or minimally invasive therapies for benign thyroid nodules 

Low molecular weight heparin versus unfractionated heparin for perioperative thromboprophylaxis in patients with cancer

Oxycodone for neuropathic pain and fibromyalgia in adults 

Partial breast irradiation for early breast cancer 

Perioperative corticosteroids for preventing complications following facial plastic surgery

Photodynamic therapy for recurrent respiratory papillomatosis 

Plasma and cerebrospinal fluid amyloid beta for the diagnosis of Alzheimer's disease dementia and other dementias in people with mild cognitive impairment (MCI) 

Rapid tests for the diagnosis of visceral leishmaniasis in patients with suspected disease

Sentinel node assessment for diagnosis of groin lymph node involvement in vulval cancer 

Single-incision sling operations for urinary incontinence in women

Systemic antibiotics for symptomatic apical periodontitis and acute apical abscess in adults 

Thermal insulation for preventing inadvertent perioperative hypothermia

The role of additional radiotherapy for primary central nervous system lymphoma 

Trastuzumab-containing regimens for metastatic breast cancer

Vitamin D supplementation for prevention of cancer in adults

Vitamins C and E for asthma and exercise-induced bronchoconstriction  

Yoga in addition to standard care for patients with haematological malignancies 


Updated Reviews

Ambulatory oxygen for people with chronic obstructive pulmonary disease who are not hypoxaemic at rest 

Angioplasty versus bare metal stenting for superficial femoral artery lesions 

Anticoagulation for the initial treatment of venous thromboembolism in patients with cancer 

Automated versus non-automated weaning for reducing the duration of mechanical ventilation for critically ill adults and children 

Bispectral index for improving anaesthetic delivery and postoperative recovery 

Bronchodilators for bronchiolitis

Calcium channel blockers for inhibiting preterm labour and birth 

Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems 

Dietary interventions (plant sterols, stanols, omega-3 fatty acids, soy protein and dietary fibers) for familial hypercholesterolaemia 

Heparin versus placebo for non-ST elevation acute coronary syndromes 

Interventions for treating phosphorus burns 

Intrapartum antibiotics for known maternal Group B streptococcal colonization 

Excimer laser refractive surgery versus phakic intraocular lenses for the correction of moderate to high myopia 

Flupenthixol decanoate (depot) for schizophrenia or other similar psychotic disorders 

Maintenance treatments for opiate -dependent adolescents 

Methotrexate for treating rheumatoid arthritis

Music therapy for people with autism spectrum disorder

Nutritional interventions for preventing and treating pressure ulcers 

Oral anticoagulation in patients with cancer who have no therapeutic or prophylactic indication for anticoagulation 

Oral misoprostol for induction of labour 

Oxytocin receptor antagonists for inhibiting preterm labour 

Physiotherapy for Parkinson's disease: a comparison of techniques

Print-based self-help interventions for smoking cessation

Positive end-expiratory pressure (PEEP) during anaesthesia for prevention of mortality and postoperative pulmonary complications 

Powered versus manual toothbrushing for oral health 

Promoting patient uptake and adherence in cardiac rehabilitation 

Psychological interventions for individuals with cystic fibrosis and their families

Retroperitoneal drainage versus no drainage after pelvic lymphadenectomy for the prevention of lymphocyst formation in patients with gynaecological malignancies 

Routine or selective carotid artery shunting for carotid endarterectomy (and different methods of monitoring in selective shunting) 

Singing as an adjunct therapy for children and adults with cystic fibrosis 

Steroidal contraceptives: effect on bone fractures in women

The role of alpha blockers prior to removal of urethral catheter for acute urinary retention in men

Ultrasound and shockwave therapy for acute fractures in adults 

Vaccines for post-exposure prophylaxis against varicella (chickenpox) in children and adults 

Vaginal prostaglandin (PGE2 and PGF2a) for induction of labour at term 

Zinc supplements for preventing otitis media 


Withdrawn Reviews

- None - 




 Preventing otitis media with pneumococcal conjugate vaccine: more data than certainty?

 Chris Del Mar & Jane Smith

 Cochrane Database Syst Rev. 2014 May 14;5:ED000082



 From observation to evidence of effectiveness: the haphazard route to finding out if a new intervention works

 Helen Handoll & Nigel Hanchard

 Cochrane Database Syst Rev. 2014 May 1;5:ED000081




New Reviews

Accommodative intraocular lens versus standard monofocal intraocular lens implantation in cataract surgery

Acupuncture for epilepsy 

Adjuvant chemotherapy for advanced endometrial cancer 

Aminoadamantanes for chronic hepatitis C 

Antibiotic therapy versus no antibiotic therapy for children aged two to 59 months with WHO-defined non-severe pneumonia and wheeze

Antibody induction versus corticosteroid induction for liver transplant recipients 

Blood pressure-lowering efficacy of monotherapy with thiazide diuretics for primary hypertension  

Botulinum toxin for upper oesophageal sphincter dysfunction in neurological swallowing disorders

Femoral nerve blocks for acute postoperative pain after knee replacement surgery  

Heparin versus normal saline for patency of arterial lines 

Hormonal contraception for women exposed to HIV infection 

Horticultural therapy for schizophrenia 

Imipramine for neuropathic pain in adults

Impact of morphine, fentanyl, oxycodone or codeine on patient consciousness, appetite and thirst when used to treat cancer pain 

Intravenous magnesium sulfate for treating adults with acute asthma in the emergency department  

Interventions for improving modifiable risk factor control in the secondary prevention of stroke

Interventions for improving sit-to-stand ability following stroke

Neostigmine for reversal of neuromuscular block in paediatric patients 

Non-invasive ventilation during exercise training for people with chronic obstructive pulmonary disease 

Pericyazine for schizophrenia 

Permissive hypoxaemia versus normoxaemia for mechanically ventilated critically ill patients

Pre-referral rectal artesunate for severe malaria  

Pressure support versus T-tube for weaning from mechanical ventilation in adults 

Prostaglandins for management of retained placenta

Psychological interventions for acute pain after open heart surgery

Sumatriptan (all routes of administration) for acute migraine attacks in adults - overview of Cochrane reviews  

Surgical management of functional bladder outlet obstruction in adults with neurogenic bladder dysfunction

Surgical treatment of stage IA2 cervical cancer  

Topical anti-inflammatory agents for seborrhoeic dermatitis of the face or scalp 

Vitamin K for improved anticoagulation control in patients receiving warfarin

Written emotional disclosure for asthma  

Yoga for the primary prevention of cardiovascular disease 

Zinc supplementation for preventing mortality, morbidity, and growth failure in children aged 6 months to 12 years of age

Zolmitriptan for acute migraine attacks in adults


Updated Reviews

Adjuvant treatment of anaplastic oligodendrogliomas and oligoastrocytomas

Angioplasty versus stenting for subclavian artery stenosis

Anti-vascular endothelial growth factor for macular oedema secondary to central retinal vein occlusion

Anticoagulants (heparin, low molecular weight heparin and oral anticoagulants) for intermittent claudication

Antimicrobial prophylaxis for colorectal surgery 

Audio-visual presentation of information for informed consent for participation in clinical trials 

Carbamazepine for schizophrenia

Conservative interventions for treating middle third clavicle fractures in adolescents and adults

Cultural competence education for health professionals

Customised versus population-based growth charts as a screening tool for detecting small for gestational age infants in low-risk pregnant women  

Early (< 8 days) postnatal corticosteroids for preventing chronic lung disease in preterm infants

Frequency of administration of erythropoiesis-stimulating agents for the anaemia of end-stage kidney disease in dialysis patients 

Group-based parent training programmes for improving parental psychosocial health

Fluid therapy for acute bacterial meningitis

Heparin for the prevention of venous thromboembolism in acutely ill medical patients (excluding stroke and myocardial infarction)  

HMG CoA reductase inhibitors (statins) for people with chronic kidney disease not requiring dialysis 

Inhaled hyperosmolar agents for bronchiectasis

Intermittent pneumatic compression for treating venous leg ulcers  

Interventions for replacing missing teeth: augmentation procedures of the maxillary sinus 

Laparoscopy for the management of acute lower abdominal pain in women of childbearing age  

Late (> 7 days) postnatal corticosteroids for chronic lung disease in preterm infants 

Mucolytics for bronchiectasis 

Nitric oxide donors for treating preterm labour 

Optimisation of antiretroviral therapy in HIV-infected children under 3 years of age

Oral herbal therapies for treating osteoarthritis 

Palivizumab for prophylaxis against respiratory syncytial virus infection in children with cystic fibrosis

Pelvic floor muscle training versus no treatment, or inactive control treatments, for urinary incontinence in women 

Preoperative education for hip or knee replacement 

Psychological therapies for the management of chronic and recurrent pain in children and adolescents 

Single dose oral etoricoxib for acute postoperative pain in adults 

Topical agents and dressings for fungating wounds 

Trypanocidal drugs for chronic asymptomatic Trypanosoma cruzi infection

Vitamin A supplementation for cystic fibrosis

Vitamin D supplementation for cystic fibrosis  


Withdrawn Reviews

Dressings for healing venous leg ulcers 

Psychological interventions for overweight or obesity 




 Taking medicines safely and effectively

 Sandy Oliver

 Cochrane Database Syst Rev. 2014 April 29;4:ED000080



 One pill, four questions: what we still need to know about reducing cardiovascular risk with combination therapy

 Alun D Hughes

 Cochrane Database Syst Rev. 2014 April 16;4:ED000079



ISSUE 4 april 2014 (COMPLETED)

New Reviews

Alpha-blockers as medical expulsive therapy for ureteral stones

Anticoagulant treatment for subsegmental pulmonary embolism 

Bone marrow versus peripheral blood allogeneic haematopoietic stem cell transplantation for haematological malignancies in adults

Cognitive behavioural therapy (brief versus standard duration) for schizophrenia  

Different regimens of intravenous sedatives or hypnotics for electroconvulsive therapy (ECT) in adult patients with depression 

Effectiveness of different treatment modalities for the management of adult-onset granulosa cell tumours of the ovary (primary and recurrent) 

Exercise-based rehabilitation for heart failure

Fixed-dose combination therapy for the prevention of cardiovascular disease

Gabapentin for chronic neuropathic pain and fibromyalgia in adults

Healthcare outcomes assessed with observational study designs compared with those assessed in randomized trials  

Immune tolerance induction for treating inhibitors in people with congenital haemophilia A or B 

Indwelling bladder catheterisation as part of intraoperative and postoperative care for caesarean section 

Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) for the diagnosis of dementia within community dwelling populations

Information provision for people with multiple sclerosis  

Interventions for iatrogenic inferior alveolar and lingual nerve injury 

Interventions for treating fingertip entrapment injuries in children 

Laparoscopic surgery for endometriosis 

Low molecular weight heparin for prevention of venous thromboembolism in patients with lower-leg immobilization 

Methods to decrease blood loss during liver resection: a network meta-analysis

Nitazoxanide for chronic hepatitis C 

Non-invasive brain stimulation techniques for chronic pain 

Non-steroidal anti-inflammatory agents to induce regression and prevent the progression of cervical intraepithelial neoplasia 

Paroxetine versus other anti-depressive agents for depression  

Post-exposure passive immunisation for preventing measles  

Rapid diagnostic tests versus clinical diagnosis for managing people with fever in malaria endemic settings 

Repositioning for pressure ulcer prevention in adults 

Screening for peripheral arterial disease

Stem cell therapy for chronic ischaemic heart disease and congestive heart failure 

Tai chi for primary prevention of cardiovascular disease  

Techniques of monitoring blood glucose during pregnancy for women with pre-existing diabetes 

The WHO Health Promoting School framework for improving the health and well-being of students and their academic achievement 

Vitamin D and vitamin D analogues for preventing fractures in post-menopausal women and older men 


Updated Reviews

Aldosterone antagonists for preventing the progression of chronic kidney disease  

Antibiotic treatment for Stenotrophomonas maltophilia in people with cystic fibrosis

Carbamazepine for chronic neuropathic pain and fibromyalgia in adults

Conservative management following closed reduction of traumatic anterior dislocation of the shoulder 

Detoxification treatments for opiate dependent adolescents 

Digitalis for treatment of heart failure in patients in sinus rhythm  

Early erythropoietin for preventing red blood cell transfusion in preterm and/or low birth weight infants

Exercise for osteoarthritis of the hip 

Formula versus donor breast milk for feeding preterm or low birth weight infants  

Higher versus lower protein intake in formula-fed low birth weight infants 

Interventions to improve safe and effective medicines use by consumers: an overview of systematic reviews 

Kangaroo mother care to reduce morbidity and mortality in low birthweight infants 

Laparoscopic versus open total mesorectal excision for rectal cancer 

Late erythropoietin for preventing red blood cell transfusion in preterm and/or low birth weight infants 

Magnesium supplementation in pregnancy 

Medically assisted hydration for adult palliative care patients 

Medically assisted nutrition for adult palliative care patients 

Neuraminidase inhibitors for preventing and treating influenza in healthy adults and children 

Nitazoxanide for chronic hepatitis C 

Oral contraceptives for functional ovarian cysts 

Physical activity programs for promoting bone mineralization and growth in preterm infants

Physical rehabilitation approaches for the recovery of function and mobility following stroke 

Planned home versus hospital care for preterm prelabour rupture of the membranes (PPROM) prior to 37 weeks' gestation 

Platelet-rich therapies for musculoskeletal soft tissue injuries 

Pneumococcal conjugate vaccines for preventing otitis media 

Probiotics for prevention of necrotizing enterocolitis in preterm infants 

Shengmai (a traditional Chinese herbal medicine) for heart failure 

Single versus combination intravenous antibiotic therapy for people with cystic fibrosis 

Sodium channel blockers for cystic fibrosis 

Steroidal contraceptives: effect on carbohydrate metabolism in women without diabetes mellitus

Sulpiride versus placebo for schizophrenia 

Treatment for peritoneal dialysis-associated peritonitis 

Type of incision for below knee amputation 


Withdrawn Reviews

Case management for persons with substance use disorders 

Non-pharmacological interventions for breathlessness in advanced stages of malignant and non-malignant diseases

Pain management for sickle cell disease in children and adults 

Preventive staff-support interventions for health workers 

Psychosocial treatment for opiate abuse and dependence 

Serotonin receptor antagonists for highly emetogenic chemotherapy in adults 

Treatment for amphetamine dependence and abuse 



 Systematic reviews of preclinical animal studies can make significant contributions to health care and more transparent translational medicine

 Merel Ritskes-Hoitinga, Marlies Leenaars, Marc Avey, Maroeska Rovers & Rob Scholten

 Cochrane Database Syst Rev. 2014 March 28;3:ED000078



ISSUE 3 March 2014 (comPlEteD)

New Reviews

Antibiotic prophylaxis for preventing post solid organ transplant tuberculosis

Artesunate plus pyronaridine for treating uncomplicated Plasmodium falciparum malaria 

Atherectomy for peripheral arterial disease 

Auditory-verbal therapy for promoting spoken language development in children with permanent hearing impairments

Behavioral interventions for improving dual-method contraceptive use 

Biocompatible dialysis fluids for peritoneal dialysis 

Biofeedback for treatment of chronic idiopathic constipation in adults 

Bronchial thermoplasty for moderate or severe persistent asthma in adults

Chinese herbal medicines for benign thyroid nodules in adults 

Chinese herbal medicines for treating osteoporosis 

Combined oral contraceptives: venous thrombosis

Computed tomography (CT) angiography for confirmation of the clinical diagnosis of brain death 

Darbepoetin for the anaemia of chronic kidney disease 

Devices for preventing percutaneous exposure injuries caused by needles in healthcare personnel 

Different unfractionated heparin doses for preventing arterial thrombosis in children undergoing cardiac catheterization

Direct composite resin fillings versus amalgam fillings for permanent or adult posterior teeth 

Direct thrombin inhibitors versus vitamin K antagonists for preventing cerebral or systemic embolism in people with non-valvular atrial fibrillation 

Endometriosis: an overview of Cochrane Reviews

Family intervention (brief) for schizophrenia  

Gloves, extra gloves or special types of gloves for preventing percutaneous exposure injuries in healthcare personnel 

High-flow nasal cannula therapy for respiratory support in children 

Inhaled steroids and risk of pneumonia for chronic obstructive pulmonary disease  

Interventions based on the Theory of Mind cognitive model for autism spectrum disorder (ASD) 

Interventions for preoperative smoking cessation 

Intraperitoneal local anaesthetic instillation versus no intraperitoneal local anaesthetic instillation for laparoscopic cholecystectomy 

Laparoscopic surgical box model training for surgical trainees with limited prior laparoscopic experience 

Lifestyle intervention for improving school achievement in overweight or obese children and adolescents

Long-acting inhaled therapy (beta-agonists, anticholinergics and steroids) for COPD: a network meta-analysis

Low molecular weight heparin for prevention of central venous catheterization-related thrombosis in children 

Methods of intraperitoneal local anaesthetic instillation for laparoscopic cholecystectomy

Non-surgical interventions for the management of chronic pelvic pain

Pharmacological interventions for prevention or treatment of postoperative pain in people undergoing laparoscopic cholecystectomy  

Pharmacotherapies for sleep disturbances in Alzheimer's disease 

Reminder systems for women with previous gestational diabetes mellitus to increase uptake of testing for type 2 diabetes or impaired glucose tolerance 

Sulthiame monotherapy for epilepsy 

Surgery or radiosurgery plus whole brain radiotherapy versus surgery or radiosurgery alone for brain metastases 

Terbutaline pump maintenance therapy after threatened preterm labour for reducing adverse neonatal outcomes 

Therapeutic ultrasound for chronic low-back pain 

Types of intraocular lenses for cataract surgery in eyes with uveitis 

Wound infiltration with locol anaesthetic agents for laparoscopic cholecystectomy


Updated Reviews

Alpha2-adrenergic agonists for the management of opioid withdrawal 

Amnioinfusion for third trimester preterm premature rupture of membranes

Antibiotics for acute bronchitis

Anticoagulation versus placebo for heart failure in sinus rhythm

Bisphosphonates for osteoporosis in people with cystic fibrosis 

Cannabinoids for epilepsy 

Exit interviews to reduce turnover amongst healthcare professionals 

Family and carer smoking control programmes for reducing children's exposure to environmental tobacco smoke

General physical health advice for people with serious mental illness 

Glycoprotein IIb-IIIa inhibitors for acute ischaemic stroke  

Hip protectors for preventing hip fractures in older people 

Interventions for improving patients' trust in doctors and groups of doctors 

Interventions for nausea and vomiting in early pregnancy 

Interventions for preoperative smoking cessation

Interventions for preventing neuropathy caused by cisplatin and related compounds 

Low pressure versus standard pressure pneumoperitoneum in laparoscopic cholecystectomy 

Methods of preventing bacterial sepsis and wound complications after liver transplantation 

Oral antiplatelet therapy for acute ischaemic stroke 

Over-the-counter (OTC) medications to reduce cough as an adjunct to antibiotics for acute pneumonia in children and adults 

Pregabalin add-on for drug-resistant partial epilepsy 

Prophylactic antibiotics to prevent surgical site infection after breast cancer surgery

Psychological therapies for thalassaemia

Pulse oximetry for perioperative monitoring  

Rehabilitation after lumbar disc surgery 

Scalpel versus no-scalpel incision for vasectomy 

Selenium for preventing cancer 

Self management for patients with chronic obstructive pulmonary disease 

Surgical interventions for high-grade vulval intraepithelial neoplasia

Systemic corticosteroids for acute sinusitis 

Timing and volume of fluid administration for patients with bleeding

Vaccines for preventing influenza in healthy adults  

Vaccines for preventing influenza in people with cystic fibrosis 

Vasectomy occlusion techniques for male sterilization 


Withdrawn Reviews

EMLA and Amethocaine for reduction of children's pain associated with needle insertion 

Music therapy for end-of-life care 

Preconception counselling for women with epilepsy to reduce adverse pregnancy outcome

Single dose dipyrone for acute postoperative pain 

Traditional Chinese medicine for epilepsy




ISSUE 2 february 2014 (COMPLETE)


New Reviews

Antibiotics for preventing suppurative complications from undifferentiated acute respiratory infections in children under five years of age 

Anticonvulsants for alcohol dependence

Aromatase inhibitors for subfertile women with polycystic ovary syndrome 

Automated weaning and spontaneous breathing trial systems versus non-automated weaning strategies for discontinuation time in invasively ventilated postoperative adults  

Blood pressure lowering efficacy of nonselective beta-blockers for primary hypertension 

Brief school-based interventions and behavioural outcomes for substance-using adolescents

Continuous interscalene brachial plexus block versus parenteral analgesia for postoperative pain relief after major shoulder surgery

Continuous versus interrupted skin sutures for non-obstetric surgery

De-escalation treatment protocols for human papillomavirus-associated oropharyngeal squamous cell carcinoma  

Dietary interventions for preventing complications in idiopathic hypercalciuria 

Exenterative surgery for recurrent gynaecological malignancies

Extracorporeal photopheresis versus alternative treatment for chronic graft-versus-host disease after haematopoietic stem cell transplantation in paediatric patients 

Extracorporeal photopheresis versus standard treatment for acute graft-versus-host disease after haematopoietic stem cell transplantation in paediatric patients 

Fewer-than-four ports versus four ports for laparoscopic cholecystectomy 

Financial interventions and movement restrictions for managing the movement of health workers between public and private organizations in low- and middle-income countries 

First-line beta-blockers versus other antihypertensive medications for chronic type B aortic dissection 

Formal education of patients about to undergo laparoscopic cholecystectomy 

Hyaluronidase for reducing perineal trauma

Intensive glucose control versus conventional glucose control for type 1 diabetes mellitus

Interventions for preventing the spread of infestation in close contacts of people with scabies 

Intravenous versus inhalational anaesthesia for paediatric outpatient surgery 

Laparoscopy for diagnosing resectability of disease in patients with advanced ovarian cancer 

Low dose naltrexone for induction of remission in Crohn's disease 

Mycophenolate mofetil for relapsing-remitting multiple sclerosis  

Non-operative versus operative treatment for blunt pancreatic trauma in children

Non-penetrating filtration surgery versus trabeculectomy for open-angle glaucoma

Peginterferon alpha-2a versus peginterferon alpha-2b for chronic hepatitis C

Peginterferon plus ribavirin versus interferon plus ribavirin for chronic hepatitis C  

Pharmacological interventions for hypertension in children 

Probiotics for preventing gestational diabetes

Psychological therapies (Internet-delivered) for the management of chronic pain in adults  

Red cell transfusion management for patients undergoing cardiac surgery for congenital heart disease 

Rehabilitation for improving automobile driving after stroke

Resection versus other treatments for locally advanced pancreatic cancer 

Safety of regular formoterol or salmeterol in adults with asthma: an overview of Cochrane reviews

Totally percutaneous versus standard femoral artery access for elective bifurcated abdominal endovascular aneurysm repair 


Updated Reviews

5-Fluorouracil for glaucoma surgery 

Adherence compounds in embryo transfer media for assisted reproductive technologies 

Antibiotics for acute maxillary sinusitis in adults 

Antihypertensive drug therapy for mild to moderate hypertension during pregnancy

Antiviral treatment for preventing postherpetic neuralgia

Aromatherapy for dementia  

Betamimetics for inhibiting preterm labour 

Buprenorphine maintenance versus placebo or methadone maintenance for opioid dependence 

Continuous passive motion following total knee arthroplasty in people with arthritis

Diacerein for osteoarthritis 

Disposable surgical face masks for preventing surgical wound infection in clean surgery 

Dopamine agents for hepatic encephalopathy

Echinacea for preventing and treating the common cold  

Elective birth at 37 weeks' gestation for women with an uncomplicated twin pregnancy

Endothelial keratoplasty versus penetrating keratoplasty for Fuchs endothelial dystrophy

Heparin-bonded catheters for prolonging the patency of central venous catheters in children 

Immediate-release versus controlled-release carbamazepine in the treatment of epilepsy

Incentive spirometry for prevention of postoperative pulmonary complications in upper abdominal surgery 

Interventions at caesarean section for reducing the risk of aspiration pneumonitis 

Light therapy for improving cognition, activities of daily living, sleep, challenging behaviour, and psychiatric disturbances in dementia

Mechanical versus manual chest compressions for cardiac arrest  

Medical treatment for botulism

Metal protein attenuating compounds for the treatment of Alzheimer's dementia

Neuraminidase inhibitors for the treatment of influenza infection in people with cystic fibrosis

Neuropsychological rehabilitation for multiple sclerosis 

Occlusion for stimulus deprivation amblyopia 

Omega 3 fatty acids (fish oil) for maintenance of remission in Crohn's disease 

Once-daily versus multiple-daily dosing with intravenous aminoglycosides for cystic fibrosis

Pressure-relieving devices for treating heel pressure ulcers  

Prophylaxis for venous thromboembolic disease in pregnancy and the early postnatal period

Psychological and behavioural treatments for adults with non-epileptic attack disorder 

Replacement versus repair of defective restorations in adults: amalgam 

Replacement versus repair of defective restorations in adults: resin composite 

Risk assessment tools for the prevention of pressure ulcers 

Screening and subsequent management for gestational diabetes for improving maternal and infant health 

Tamponade in surgery for retinal detachment associated with proliferative vitreoretinopathy

Tiagabine add-on for drug-resistant partial epilepsy

Tocolytics for preterm premature rupture of membranes 

Topiramate add-on for drug-resistant partial epilepsy 

Transtheoretical model stages of change for dietary and physical exercise modification in weight loss management for overweight and obese adults

Treatment for primary postpartum haemorrhage

Vision screening of older drivers for preventing road traffic injuries and fatalities

Voriconazole versus amphotericin B or fluconazole in cancer patients with neutropenia

Workplace interventions for smoking cessation  


Withdrawn Reviews

Dietary interventions for recurrent abdominal pain (RAP) and irritable bowel syndrome (IBS) in childhood

Interventions for drug-using offenders in the courts, secure establishments and the community

Pharmacological interventions for recurrent abdominal pain (RAP) and irritable bowel syndrome (IBS) in childhood

Psychosocial interventions for recurrent abdominal pain (RAP) and irritable bowel syndrome (IBS) in childhood 


ISSUE 1 JANUARY 2014 (completed)



 Annika Strandell 

 Cochrane Database Syst Rev. 2014 January 14;1:ED000077


New Reviews

Amplification with hearing aids for patients with tinnitus and co-existing hearing loss 

Anaesthetic regimens for day-procedure laparoscopic cholecystectomy

Calcium channel blockers for primary Raynaud's phenomenon 

Clonidine premedication for postoperative analgesia in children 

Complement inhibitors for age-related macular degeneration

Dexmedetomidine for the management of awake fibreoptic intubation

Dihydroartemisinin-piperaquine for treating uncomplicated Plasmodium falciparum malaria

EEG for children with complex febrile seizures 

Endoscopic release for carpal tunnel syndrome 

Endovascular repair of abdominal aortic aneurysm 

Helminth therapy (worms) for induction of remission in inflammatory bowel disease

High-flow nasal cannula therapy for infants with bronchiolitis

Image guided surgery for the resection of brain tumours 

Implementation of treatment guidelines for specialist mental health care  

Inotropic agents and vasodilator strategies for acute myocardial infarction complicated by cardiogenic shock or low cardiac output syndrome

Intermittent versus daily therapy for treating tuberculosis in children 

Interventions for drug-using offenders with co-occurring mental illness 

Interventions for female drug-using offenders 

Interventions for preventing delirium in older people in institutional long-term care

Laparoscopic surgical box model training for surgical trainees with no prior laparoscopic experience 

Neuraxial blockade for the prevention of postoperative mortality and major morbidity: an overview of Cochrane systematic reviews 

Peroxisome proliferator-activated receptor gamma agonists for preventing recurrent stroke and other vascular events in patients with stroke or transient ischaemic attack 

Phacoemulsification with posterior chamber intraocular lens versus extracapsular cataract extraction (ECCE) with posterior chamber intraocular lens for age-related cataract 

Pharmacological treatment of vascular risk factors for reducing mortality and cardiovascular events in patients with abdominal aortic aneurysm

Psychological treatments for depression and anxiety in dementia and mild cognitive impairment 

Self-management education programmes for osteoarthritis 

Skin-to-skin care for procedural pain in neonates

Stiripentol for focal refractory epilepsy

Subcutaneous closure versus no subcutaneous closure after non-caesarean surgical procedures 

The role of high-frequency oscillations in epilepsy surgery planning

Tracheal intubation with a flexible intubation scope versus other intubation techniques for obese patients requiring general anaesthesia  

Treatment of Kaposi sarcoma in children with HIV-1 infection 

Trifluoperazine versus placebo for schizophrenia

Yellow fever vaccine for patients with HIV infection 


Updated Reviews

Acupuncture and related interventions for smoking cessation

Addition to inhaled corticosteroids of long-acting beta2-agonists versus anti-leukotrienes for chronic asthma 

Amnioinfusion for meconium-stained liquor in labour 

Antibiotics and antiseptics for venous leg ulcers 

Antidepressants for smoking cessation 

Antiepileptic drugs for the primary and secondary prevention of seizures after stroke 

Aripiprazole versus other atypical antipsychotics for schizophrenia 

Beta lactam antibiotic monotherapy versus beta lactam-aminoglycoside antibiotic combination therapy for sepsis 

Chlorpromazine versus placebo for schizophrenia

Combination contraceptives: effects on weight 

Decision aids for people facing health treatment or screening decisions 

Duloxetine for treating painful neuropathy, chronic pain or fibromyalgia 

Educational, supportive and behavioural interventions to improve usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

Empirical antibiotics targeting Gram-positive bacteria for the treatment of febrile neutropenic patients with cancer

Enzyme replacement therapy with idursulfase for mucopolysaccharidosis type II (Hunter syndrome) 

HMG CoA reductase inhibitors (statins) for kidney transplant recipients 

Insulin for glycaemic control in acute ischaemic stroke 

Interventions for Mooren's ulcer 

Interventions for preventing critical illness polyneuropathy and critical illness myopathy 

Interventions for the treatment of twin-twin transfusion syndrome 

Intravascular brachytherapy for peripheral vascular disease

Kinship care for the safety, permanency, and well-being of children removed from the home for maltreatment

Length of hospitalisation for people with severe mental illness 

Management of faecal incontinence and constipation in adults with central neurological diseases

Omalizumab for asthma in adults and children

Ovulation triggers in anovulatory women undergoing ovulation induction 

Perazine for schizophrenia 

Physical health care monitoring for people with serious mental illness 

Progestational agents for treating threatened or established preterm labour 

Psychological and educational interventions for atopic eczema in children 

Regular long-term red blood cell transfusions for managing chronic chest complications in sickle cell disease

Respite care for people with dementia and their carers

Routine vitamin A supplementation for the prevention of blindness due to measles infection in children 

Thrombolysis for acute deep vein thrombosis

Treadmill training and body weight support for walking after stroke  

Vaccines for preventing typhoid fever

Vitamin D supplementation for prevention of mortality in adults

Xpert® MTB/RIF assay for pulmonary tuberculosis and rifampicin resistance in adults


Withdrawn Reviews

Interventions to promote the wearing of hearing protection (Withdrawn) 



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