Research teams who prepare Cochrane Reviews are made up almost entirely of volunteers. The task is onerous, perhaps more so than people who come to this for the first time can imagine, and over time it has become more challenging, as methods aimed at improving internal and external validity advance...
Myocardial infarction occurs when heart muscle cells die as a consequence of oxygen deprivation. Occasionally this can happen when the oxygen-carrying capacity of the blood is reduced, and there is general hypoxaemia...
International Clinical Trials Day, 20 May 2010, is an opportunity to celebrate the role of clinical trials in resolving uncertainties in health care and a fitting day to mark within The Cochrane Library. A related series of podcasts discussing various aspects of clinical trials are available within the Special Collection for International Clinical Trials Day...
One of the common criticisms made of The Cochrane Collaboration is that most of its reviews don’t end with clear instructions for action by professionals, patients and policymakers. Since its inception, however, the Collaboration has made it clear that research evidence isn’t everything. Other factors need to be taken into account when people decide what action – if any – is needed when making treatment and policy decisions...
In order to optimize health outcomes within the constraints of inevitably limited resources, low- and high-income countries alike require unbiased means of assessing health care interventions for their relative effectiveness. Such interventions include diagnostic tests and treatments (both established and newly developed) and implementation of health policy...
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